Search Results for: sign of leser-trelat

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A Clinical Atlas of 101 Common Skin Diseases


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An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammation, and fibrosis.

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

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A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp.

A Clinical Atlas of 101 Common Skin Diseases


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A constellation of lesions that represent disorders of melanocytes (e.g., axillary “freckles” and café au lait “spots”) and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma).

A Clinical Atlas of 101 Common Skin Diseases

Pruritic Urticarial Papules and Plaques of Pregnancy

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An inflammatory process in pregnant women near term that consists of urticarial papules and plaques, especially on the trunk and particularly in association with lesions of striae atrophicantes, the lesions disappearing shortly after parturition.

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…tosis. Mast cells in the skin represent a large concentration of inflammatory mediators, as mast cells often contain granules of histamine. Stroking or rubbing a lesion of cutaneous mastocytosis can elaborate these signaling molecules, and often resu…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Key Points

…healing. PG lesions may be exquisitely painful, sometimes out of proportion to their clinical appearance or size; reduction in pain associated with a lesion represents an important early sign of effective treatment. Lesions often heal with a very cha…

Therapeutic Strategies in Dermatology

Drug Eruptions: Therapy

…ularly if drugs such as dilantin and allopurinol are possible offenders. Common findings of systemic involvement include: leukocytosis, eosinophilia, thrombocytopenia, renal impairment, transaminitis, and elevated creatine kinase (sign of myositis)….

Therapeutic Strategies in Dermatology

Keratosis Pilaris: Treatment

…ent therapy After the keratinous plugs have been removed, use of an emollient cream containing 20% urea (Carmol) may prevent reappearance of lesions. Use of the abrasive scrub pad should be resumed at the first sign of reappearance of crops of new le…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…all ethnic groups and age ranges, with an overall prevalence of 10-40 cases per 100,000 persons, the annual incidence in African Americans is significantly higher, while that in Japanese is markedly lower. Scandinavia has the world’s highest prevale…

Therapeutic Strategies in Dermatology

Atopic Dermatitis: Initial Evaluation

…, a commonly-affected site. Lichenification resulting in loss of the lateral aspect of the eyebrows, also known as Hertoghe’s sign. Hypopigmented patches with subtle scale in atopic dermatitis, also known as pityriasis alba. Fissuring is common in th…

Therapeutic Strategies in Dermatology

Angular Cheilitis: Treatment

…e, folic acid, niacin, and zinc deficiencies) are rare causes of perlèche. Perlèche, especially when unilateral, that fails to respond as expected may be a sign of a mucocutaneous malignancy. In edentulous and immunosuppressed patients, candidiasis m…

Therapeutic Strategies in Dermatology

Syphilis (Lues): Key Points

…ts across a broad clinical spectrum, including many cutaneous signs, that evolves with the duration of the infection and also correlates with the immune status of the patient. Table 1. Cutaneous and Systemic Findings in Syphilis Key cutaneous finding…

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