Therapeutic Strategies in Dermatology

Keloids and Hypertrophic Scars: Treatment

…(see Pitfalls). There is mixed evidence supporting the use of silicone sheeting for scarring and it may be effective if used early in wound healing. In some trials, silicone sheeting was effective in 70-80% of cases to avoid keloid formation. The ev…

Therapeutic Strategies in Dermatology

Epidermolysis Bullosa: Overview

Overview Epidermolysis bullosa (EB) is a heterogeneous group of inherited mechanobullous diseases. Three basic forms are recognized, based on the electron microscopic level of the blister formation. The ideal strategy would be to correct the genetic…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rophages with abundant finely vacuolated and clear cytoplasm = Silicone granuloma Silicone injected into the skin may act just as much like a foreign body as a splinter or a suture. A foreign body reaction, however, need not necessarily be accompanie…

Histologic Diagnosis of Inflammatory Skin Diseases

Silica granuloma

…de) is the chief constituent of sand and, therefore, of glass. Silicone, by contrast, is a plastic compound of silicon oxide and, depending on the extent of polymerization, may present itself as a liquid, gel, or solid. Both compounds, silica and sil…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

Xanthomas Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized or widespread Individual lesions Macules, papules, plaques, and nodules Course Some lesions, e.g., eruptive xanthomas, involuting when serum lipi…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

Foreign body reaction Synonyms Foreign body granuloma Presentation stereotypical Age and sex Any age and either sex Distribution of lesions Localized usually Individual lesions Papules, plaques, and nodules Course Longstanding Variations clinical…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

“Scleroderma is a chronic disease of unknown cause that affects the microvasculature and loose connective tissue and is characterized by fibrosis and obliteration of vessels in the skin, lungs, gastrointestinal tract, kidneys and heart. It m…