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Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…d type. Figure 5.84 A&B. Ballooning in conjunction with spongiosis: prurigo pigmentosa. The occurrence, jointly, of ballooning and spongiosis is common in prurigo pigmentosa, depicted here and characterized, too, by neutrophils in the edematou…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…ontact dermatitis (and nummular dermatitis): intraspinous with spongiosis. In allergic contact dermatitis, and its lookalike, nummular dermatitis, the blister begins in the epidermal spinous zone, first as spongiosis, seen here in the lower part of t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…is fungoides sometimes do that and in the absence of prominent spongiosis (and serum) as pictured. In no inflammatory disease of the skin are so many lymphocytes present in the epidermis with so little spongiosis there as there are in mycosis fungoid…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then are added to a particular “nonspecific” finding, beginning with those attributes discernable at moderately high magnification and processing to those visualizable at progressively lower […]

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…resent in the epidermis, but accompanied there by little or no spongiosis. That some spongiosis, however scant, must have been present in the epidermis may be inferred from the presence of tiny globules of serum that often reside in elongated mounds…

Histologic Diagnosis of Inflammatory Skin Diseases

Infundibulofolliculitis, disseminate and recurrent

…developed Superficial perivascular infiltrate of lymphocytes Spongiosis in infundibula Correlation clinicopathologic Spongiosis in infundibula is responsible for the appearance of tiny infundibulocentric papules. Differential diagnosis histopathol…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.66.1A: Perivascular dermatitis, interface, vacuolar + 10.66.1B: Lymphocytes along the dermoepidermal junction and in the spinous zone, and ballooned and necrotic keratocytes = Mucha-Habermann disease, acute That this lesion is r…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…around vessels, thin rete ridges of about equal length, marked spongiosis, and scale-crusts arrayed in staggered fashion = Psoriasis, fully developed ¬†On volar skin, psoriasis often is associated with prominent spongiosis and, sometimes, spongiotic v…

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