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Therapeutic Strategies in Dermatology

Lupus: Key Points

…interface involvement, with the focus of inflammation in the subcutaneous fat. A direct immunofluorescence testing of the skin biopsy will reveal characteristic patterns, depending on the form of cutaneous lupus. The goal of treatment for cutaneous…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…cutaneous involvement or may be symptomatic lesions with deep subcutaneous involvement (such as certain vascular malformations). Introduction Vascular birthmarks may be divided into vascular tumors, such as a hemangioma of infancy, and vascular malf…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…ents as localized disease, generalized plaques or papules, or subcutaneous nodules. Granuloma annulare may be associated with internal disease such as diabetes, hyperlipidemia, thyroid disease, or HIV, albeit in limited studies. Malignancy associated…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…: Recombinant, humanized IgG against TNF-A. It is given as a subcutaneous injection weekly or every other week. Approximately 75% patients may achieve 75% improvement in the PASI score at 16 weeks into the treatment versus approximately 10-20% of pl…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…e Serum LDH M0 No distant metastases NA M1a Distant skin, subcutaneous, or nodal metastases Normal M1b Lung metastases Normal M1c All other visceral metastases Normal Any distant metastases Elevated Abbreviations: NA, not applicable; LD…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…“equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tissue, that run at right angles to one another, into discrete, large rectangular units composed of adipocytes. The struts ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

Subcutaneous fat necrosis of the newborn Synonyms Adiponecrosis subcutanea neonatorum Presentation stereotypical Age and sex Healthy full-term newborns Distribution of lesions Buttocks, thighs, shoulders, back, or arms Individual lesions Dusky-red n…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat

The subcutaneous fat, like the dermis, is derived embryologically from mesenchyme. Primitive mesenchymal cells give rise to fibrocytes and to adipocytes. An adipocyte synthesizes so much fat in its cytoplasm that the lipid displaces and flattens the…

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