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Therapeutic Strategies in Dermatology

Lupus: Key Points

…d interface involvement, with the focus of inflammation in the subcutaneous fat. A direct immunofluorescence testing of the skin biopsy will reveal characteristic patterns, depending on the form of cutaneous lupus. The goal of treatment for cutaneous…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

Key Points Vascular birthmarks are cutaneous vascular lesions present at, or shortly after, birth. They may be categorized as vascular tumors or vascular malformations. The term hemangioma has previously been used to describe many common, typicall…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

Principles of Psoriasis Management Topical therapy is usually appropriate for treatment of patients with less than 10% body surface area (see table below). Systemic therapies (see table below) are indicated when one or more of the following are pre…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…IV Invasion into the reticular dermis without involvement of subcutaneous tissue V Invasion into subcutaneous tissue In this chapter, only treatment of primary lesions is discussed. Treatment of melanoma is mainly surgical. Although occasional…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…le because the blade of a microtome in its random pass through fat cells in lobules fails to engage more than a minuscule minority of nuclei. Some inflammatory diseases target the subcutaneous fat and it is there principally that findings histopathol…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

Subcutaneous fat necrosis of the newborn Synonyms Adiponecrosis subcutanea neonatorum Presentation stereotypical Age and sex Healthy full-term newborns Distribution of lesions Buttocks, thighs, shoulders, back, or arms Individual lesions Dusky-red n…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat

…osed largely of bundles of collagen, divide conglomerations of subcutaneous adipocytes into lobules. The fibrous septa also house muscle-containing vessels, lymphatics, and nerves. (x25) Arteries and veins in the subcutaneous fat are positioned withi…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…of neoplastic lymphocytes accompanied by inflammatory cells in fat lobules and in the deep reticular dermis. Fibrosis replaces zones of necrosis in the subcutaneous fat and sometimes is manifested clinically by gullies at affected sites. Differential…

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