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A Clinical Atlas of 101 Common Skin Diseases

Dermatofibroma

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An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammation, and fibrosis.

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

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A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp.

A Clinical Atlas of 101 Common Skin Diseases

Erythema Annulare Centrifugum

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An inflammatory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence of treatment.

A Clinical Atlas of 101 Common Skin Diseases

Erythema Multiforme

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An inflammatory process that tends to involve mucous membranes, as well as skin, and of the latter the acra especially.

A Clinical Atlas of 101 Common Skin Diseases

Erythema Nodosum

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An inflammatory process, i.e., a panniculitis, marked by tender erythematous plaques, nodules, or tumors (or combinations thereof) that usually affect the anterior aspect of the legs and, less often, the arms, and induced by processes, in an organ other than the skin, as dissimilar as sarcoidosis, Crohn’s disease, and histoplasmosis.

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

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An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrophy and hyperpigmentation (classic discoid lupus erythematosus), arcuate, annular, and serpiginous lesions (subacute cutaneous lupus erythematosus), nonscaling plaques (tumid lupus erythematosus), subcutaneous nodules (lupus profundus), and blisters (bullous lupus erythematosus).

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

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A constellation of lesions that represent disorders of melanocytes (e.g., axillary "freckles" and café au lait "spots") and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma).

A Clinical Atlas of 101 Common Skin Diseases

Pruritic Urticarial Papules and Plaques of Pregnancy

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An inflammatory process in pregnant women near term that consists of urticarial papules and plaques, especially on the trunk and particularly in association with lesions of striae atrophicantes, the lesions disappearing shortly after parturition.

A Clinical Atlas of 101 Common Skin Diseases

Viral Exanthems

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An inflammatory process manifested by a transient, usually widespread eruption, made up typically of macules and papules, and episodically of vesicles and pustules.

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…fficacy and safety of these drugs in the pediatric population. They should be administered by specialists. Etanercept (Enbrel): Recombinant, human protein that was designed to block the proinflammatory and hyperproliferative actions of tumor necros…

Therapeutic Strategies in Dermatology

Lupus: Key Points

…bullous lesions clinically and histologically, the infiltrate of which may be comprised of neutrophils rather than lymphocytes. Lupus profundus has less epidermal and interface involvement, with the focus of inflammation in the subcutaneous fat. A d…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

Subcutaneous fat necrosis of the newborn Synonyms Adiponecrosis subcutanea neonatorum Presentation stereotypical Age and sex Healthy full-term newborns Distribution of lesions Buttocks, thighs, shoulders, back, or arms Individual lesions Dusky-red n…

Therapeutic Strategies in Dermatology

Spider Bites: Key Points

…are several medically important spiders designated so because of cytotoxic factors introduced by their bites; these can result in inflammation and necrosis of the skin. Some spider bites can result in systemic symptoms. Fatal spider bites are extrem…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…scular birthmarks that present in infancy with a wide spectrum of clinical presentations. Recent changes in the classification now restrict the term hemangioma to describe hemangioma of infancy, a benign, self-involuting, endothelial tumor that prese…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…II Invasion of papillary dermis only without involvement of the papillary-reticular dermal interface III Invasion to the papillary dermis without extension into the reticular dermis IV Invasion into the reticular dermis without involvement of…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…ative beyond doubt of fat necrosis: Figure 5.401 Five signs of necrosis of adipocytes. A. Granular fat necrosis. B. Fat “microcysts.” C. Membranous fat necrosis. D. Foamy histiocytes (foam cells, lipophages). E. Calcification in the su…

Therapeutic Strategies in Dermatology

Spider Bites: Treatment

Treatment Spider bites of Loxosceles reclusa First steps First-line therapy involves localized wound care. Elevate and rest the bitten area. Apply ice, not heat. Give analgesics as needed for pain. The use of systemic agents such as dapsone or cor…

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