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Therapeutic Strategies in Dermatology

Epidermolysis Bullosa: Overview

…osporin. Perform cultures, as antibiotic resistance may occur. Blister care: The normal skin forming the roof of the blister should be left on as long as possible; it is the optimal biologic dressing. If the hydrostatic pressure of the fluid in the b…

Therapeutic Strategies in Dermatology

Warts: Treatment

Treatment First-line therapy: The first-line therapy for warts involves destructive methods tailored to the type of wart. Destruction of wart lesions may be accomplished using cryosurgical or electrosurgical techniques, chemical destruction either…

Therapeutic Strategies in Dermatology

Epidermolysis Bullosa Acquisita: Overview

…split skin, staining of histologic sections demonstrating the blister to identify laminin at the roof of the blister, or with electron microscopy. Therapy is generally difficult, and most patients have a chronic progressive disorder lasting many yea…

Therapeutic Strategies in Dermatology

Linear IgA Dermatosis: Overview

Overview Linear IgA dermatosis is a bullous disorder that resembles dermatitis herpetiformis or bullous pemphigoid but is distinguished from these disorders by the linear deposition of IgA at the epidermodermal junction and the absence of gluten-sen…

Histologic Diagnosis of Inflammatory Skin Diseases

Suction blister

Suction blister Presentation stereotypical Individual lesions Vesicles and bullae Findings histopathologic Fully developed Subepidermal blister beneath which dermal papillae are preserved No infiltrate of inflammatory cells Correlation clinicopath…

A Clinical Atlas of 101 Common Skin Diseases

Pemphigus Foliaceus

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Overview

Overview Bullous pemphigoid is usually a self-limited inflammatory subepidermal blistering disorder of the elderly, in which circulating auto antibodies to epitopes in the basement membrane zone bind to this region and initiate a cascade of inflamma…

Therapeutic Strategies in Dermatology

Pemphigus Foliaceus, Pemphigus Erythematosus: Overview

Overview Pemphigus foliaceus is a relatively benign autoimmune bullous disease associated with the deposition of intercellular antibodies directed against desmoglien 1. The therapeutic approach differs significantly from that for pemphigus vulgaris;…

Therapeutic Strategies in Dermatology

Impetigo: Key Points

Key Points Impetigo is a highly contagious superficial cutaneous infection by Staphylococcus aureus and/or Streptococcus pyogenes. Effective treatment is directed at both organisms. Secondary impetigo, or impetiginization, may complicate preexistin…

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