Search Results for: touton giant cells

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A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Therapeutic Strategies in Dermatology

Herpes Simplex: Clinical Cases

…nck smear of blister fluid reveals presence of multinucleated giant cells Viral DFA and culture for HSV obtained Acyclovir 400 mg p.o. t.i.d. x 5 days Follow-up in 1 week Follow-up visit Lesions resolving HSV DFA is positive and viral culture reveals…

A Clinical Atlas of 101 Common Skin Diseases


A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…on-caseating granulomas composed of groups of histiocytes and giant cells, with a sparse rim of lymphocytes (so-called “naked” granulomas). These foci of granulomatous infiltrates may occur throughout the body; the distribution of inflammation determ…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…s are recognized by criteria morphologic: (1) Langhans” giant cells, seen commonly in tuberculoid granulomas and characterized by a horseshoe-shaped rim of nuclei at the outermost part of abundant eosinophilic cytoplasm; (2) Touton giant cells

A Clinical Atlas of 101 Common Skin Diseases


…au lait “spots”) and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutaneous lesions may be accompanied by neoplasms with neural differentiation that are situated in nerves (e.g., acoustic ne…

Therapeutic Strategies in Dermatology

Folliculitis (including pseudofolliculitis barbae): Key Points

…ir follicle, resulting in abscess formation or a foreign-body giant cell reaction in a follicle-based distribution. It is often exacerbated by shaving and/or waxing, and resolves when the inciting form of hair removal is stopped. There are several ba…

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