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Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…es are recognized by criteria morphologic: (1) Langhans” giant cells, seen commonly in tuberculoid granulomas and characterized by a horseshoe-shaped rim of nuclei at the outermost part of abundant eosinophilic cytoplasm; (2) Touton giant cells

Therapeutic Strategies in Dermatology

Herpes Simplex: Clinical Cases

…anck smear of blister fluid reveals presence of multinucleated giant cells Viral DFA and culture for HSV obtained Acyclovir 400 mg p.o. t.i.d. x 5 days Follow-up in 1 week Follow-up visit Lesions resolving HSV DFA is positive and viral culture reve…

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…non-caseating granulomas composed of groups of histiocytes and giant cells, with a sparse rim of lymphocytes (so-called “naked” granulomas). These foci of granulomatous infiltrates may occur throughout the body; the distribution of inflammation deter…

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

A constellation of lesions that represent disorders of melanocytes (e.g., axillary “freckles” and café au lait “spots”) and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutaneou…

Therapeutic Strategies in Dermatology

Folliculitis (including pseudofolliculitis barbae): Key Points

Key Points Folliculitis is a term that encompasses follicular-based inflamed papules or pustules that may stem from a wide variety of causes. Important causes of folliculitis include infection (bacterial, yeast, and viral), friction, medication-in…

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