Search Results for: touton giant cells

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Therapeutic Strategies in Dermatology

Necrobiosis Lipoidica Diabeticorum: Key Points

…obiotic” collagen, which appears as homogenized pink bands. The inflammatory component may have palisades of histiocytes and giant cells; plasma cells are often noted near the deeper component. The alternating bands of inflammation and…

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…t Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential diagnosis…

Therapeutic Strategies in Dermatology

Herpes Simplex: Clinical Cases

…lateral, external aspect of his lower lip; no other lesions Tzanck smear of blister fluid reveals presence of multinucleated giant cells Viral DFA and culture for HSV obtained Acyclovir 400 mg p.o. t.i.d. x 5 days Follow-up in 1 week Follow-up visit…

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…nfiltrates of macrophages and lymphocytes that aggregate into non-caseating granulomas composed of groups of histiocytes and giant cells, with a sparse rim of lymphocytes (so-called “naked” granulomas). These foci of granulomatous infiltrates may…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…If the granulomatous response is sustained, histiocytes become epithelioid and may fuse to become multinucleate (histiocytic giant cells). Three types of multinucleate histiocytes are recognized by criteria morphologic: (1) Langhans” giant

Therapeutic Strategies in Dermatology

Folliculitis (including pseudofolliculitis barbae): Key Points

…y stems from inward growth of tightly curled hair within the hair follicle, resulting in abscess formation or a foreign-body giant cell reaction in a follicle-based distribution. It is often exacerbated by shaving and/or waxing, and resolves when…

Therapeutic Strategies in Dermatology

Varicella & Herpes Zoster: Initial Evaluation

…a swab from the base of a vesicle. A Tzanck preparation can provide a rapid result (demonstrating the classic multinucleate giant cells), however, is not able to distinguish VZV from herpes simplex virus infection. Skin biopsy of a lesion can also…

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