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A Clinical Atlas of 101 Common Skin Diseases

Dermatofibroma

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An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammation, and fibrosis.

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

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A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp.

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

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A constellation of lesions that represent disorders of melanocytes (e.g., axillary “freckles” and cafĂ© au lait “spots”) and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma).

A Clinical Atlas of 101 Common Skin Diseases

Pruritic Urticarial Papules and Plaques of Pregnancy

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An inflammatory process in pregnant women near term that consists of urticarial papules and plaques, especially on the trunk and particularly in association with lesions of striae atrophicantes, the lesions disappearing shortly after parturition.

Therapeutic Strategies in Dermatology

Melanoma: Key Points

Key Points The therapy of malignant melanoma is determined by the histopathologic features (primarily tumor thickness, ulceration, regression, and mitotic index), by the location of the tumor, by the presence of regional or distant metastases and b…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…sduction inhibitors – extend overall survival. Selection of these agents should be guided by specific (FDA approved) genetic testing of the tumor to determine whether the melanoma tumor carries mutations in the targeted pathway, i.e., dabrafeni…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…scular birthmarks that present in infancy with a wide spectrum of clinical presentations. Recent changes in the classification now restrict the term hemangioma to describe hemangioma of infancy, a benign, self-involuting, endothelial tumor that prese…

Therapeutic Strategies in Dermatology

Folliculitis (including pseudofolliculitis barbae): Key Points

…Gram-negative forms occur, usually on the face, in the setting of chronic, broad-spectrum antibiotic therapy of acne vulgaris. Since inflammation is limited to the hair follicle, classic signs of infection (dolor, calor, rubor, and tumor) may be abse…

Therapeutic Strategies in Dermatology

Flushing: Clinical Case

…ated triggers such as foods or other ingestions, also no signs of lip, tongue, throat swelling nor bronchospasm. No significant past medical history or family history. She takes no medications except for multivitamins daily Review of systems is notab…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…T lymphocyte driven, immune-mediated disorder. The development of a new class of drugs, engineered proteins targeting specific immunologic mediators involved in psoriasis, including tumor necrosis factor alpha (TNF-A), may offer effective treatments…

A Clinical Atlas of 101 Common Skin Diseases

Cysts and Cystic Hamartomas

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Therapeutic Strategies in Dermatology

Keratosis Pilaris: Key Points

…atch. On biopsy, these lesions are characterized by keratinous follicular plugging with orthohyperkeratosis to create a follicular spicule. Typical sites of involvement include facial cheeks, upper posterior arms, lateral thighs, and buttocks, and in…

Therapeutic Strategies in Dermatology

Vitiligo: Clinical Cases

…-up Approximately 50% repigmentation noted (with accentuation of repigmentation at follicular areas) Recommend continued application of calcineurin ointment Follow-up in six months Six-month follow-up Approximately 75% repigmentation noted Recomme…

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