A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

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Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia.

A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…Hu JA, Li YN, Li SY, Ying H. [Study of the clinicopathology on verruciform xanthoma of the oral cavity.] Shanghai Kou Qiang Yi Xue. 2005;14(4):370-73. Shafer, in 1971, was the first to call attention to verruciform xanthoma as a distinctive conditio…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Eruptive xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

Xanthomas Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized or widespread Individual lesions Macules, papules, plaques, and nodules Course Some lesions, e.g., eruptive xanthomas, involuting when serum lipi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…th of foamy histiocytes across the upper third of the dermis = Xanthoma disseminatum + Acanthosis, usually verrucous, and foamy histiocytes confined to the papillary dermis = Verruciform xanthoma + Foamy histiocytes around infundibula widened mar…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…cytic-associated disorders of adults A. Normolipemic cutaneous xanthomatosis 1. Papular 2. Generalized xanthelasma 3. Solitary and eruptive xanthogranuloma 4. Necrobiotic xanthogranuloma 5. Xanthoma disseminatum 6. Subcutaneous xanthomatosis B. Multi…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…e xanthogranuloma Nevoxanthoendothelioma Nevoxanthoma Juvenile xanthoma Juvenile giant cell granuloma Xanthoma multiplex Multiple eruptive xanthoma in infancy Congenital xanthoma tuberosum Xanthoma naeviforme Presentation stereotypical Age and sex Y…

Differential Diagnosis in Dermatopathology

Discussions

…-threatening atherosclerotic cardiovascular disease. Tendinous xanthomas arise in tendons, ligaments, and fascia as skin-colored or slightly yellow papules that become nodules and sometimes tumors. Tuberous xanthomas begin as small, soft, yellow-to-r…