A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

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Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia.

A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…nce.” Zegaralli DJ, Zegarelli-Schmidt EC, Zegarelli EV. Verruciform xanthoma. Oral Surg, Oral Med, Oral Pathol 1974;38(5):725–34. “Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Eruptive xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…ve condition, one that has yet to be defined with clarity, is verruciform xanthoma, a condition marked by a combination of papillated acanthosis and a diffuse infiltrate of foam cells that reside just beneath the thickened epithelium. We deem verruco…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…lprin KM, Lorincz AL. Disseminated xanthosiderohistiocytosis (xanthoma disseminatum). Arch Dermatol 1960;82:172–82. “The histiocytic disorders cover a wide range of primary and secondary, solitary and multiple, benign and malignant diso…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…h of foamy histiocytes across the upper third of the dermis = Xanthoma disseminatum + Acanthosis, usually verrucous, and foamy histiocytes confined to the papillary dermis = Verruciform xanthoma + Foamy histiocytes around infundibula widened mark…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…Synonyms Juvenile xanthogranuloma Nevoxanthoendothelioma Nevoxanthoma Juvenile xanthoma Juvenile giant cell granuloma Xanthoma multiplex Multiple eruptive xanthoma in infancy Congenital xanthoma tuberosum Xanthoma naeviforme Presentation stereotypi…

Differential Diagnosis in Dermatopathology

Discussions

The most important finding that granular-cell tumors and xanthomas have in common is diffuse dermal infiltrates of monomorphous cells that possess abundant pale-staining cytoplasm. The cytoplasm may have either a basophilic or eosinophilic hue in se…