A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

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Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia.

A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…Zegaralli DJ, Zegarelli-Schmidt EC, Zegarelli EV. Verruciform xanthoma. Oral Surg, Oral Med, Oral Pathol 1974;38(5):725–34. “Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that,…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Eruptive xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…les, plaques, and nodules Course Some lesions, e.g., eruptive xanthomas, involuting when serum lipid levels are lowered markedly; others, e.g., xanthoma tuberosum and tendinosum, persisting Variations clinical Xanthelasma are plaques on the eyelids…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…lprin KM, Lorincz AL. Disseminated xanthosiderohistiocytosis (xanthoma disseminatum). Arch Dermatol 1960;82:172–82. “The histiocytic disorders cover a wide range of primary and secondary, solitary and multiple, benign and malignant diso…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…Synonyms Juvenile xanthogranuloma Nevoxanthoendothelioma Nevoxanthoma Juvenile xanthoma Juvenile giant cell granuloma Xanthoma multiplex Multiple eruptive xanthoma in infancy Congenital xanthoma tuberosum Xanthoma naeviforme Presentation stereotypi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…nd scattered interstitially in conjunction with neutrophils = Xanthoma, eruptive + Foamy histiocytes in nodules throughout the dermis and subcutis of volar skin or skin near it = Xanthoma tendinosum and tuberosum + Midreticular dermis of volar sk…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…by the absence of accompanying lymphocytes, plasma cells, eosinophils, and neutrophils. The presence of fibroplasia is not differentiating because it may be seen in some xanthomas, e.g., tuberosum and tendinosum, as well as in xanthogranulomas….