A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

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Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia.

A Clinical Atlas of 101 Common Skin Diseases

Xanthomas, Including Xanthogranulomas

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…Zegaralli DJ, Zegarelli-Schmidt EC, Zegarelli EV. Verruciform xanthoma. Oral Surg, Oral Med, Oral Pathol 1974;38(5):725–34. “Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that,…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Eruptive xanthoma

Deposits of lipid in the skin and sometimes in subcutaneous tissues as a consequence often, but not always, of hyperlipidemia. The lipid deposits are expressed as yellowish papules and plaques, and nodules and tumors….

A Clinical Atlas of 101 Common Skin Diseases

Xanthogranuloma

A granulomatous inflammatory process that presents itself in children as multiple yellowish papules or nodules that often are associated with systemic involvement of eyes, liver, and testes. In adults it is usually a solitary lesion confined to the…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…ules, plaques, and nodules Course Some lesions, e.g., eruptive xanthomas, involuting when serum lipid levels are lowered markedly; others, e.g., xanthoma tuberosum and tendinosum, persisting Variations clinical Xanthelasma are plaques on the eyelids…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…e xanthogranuloma Nevoxanthoendothelioma Nevoxanthoma Juvenile xanthoma Juvenile giant cell granuloma Xanthoma multiplex Multiple eruptive xanthoma in infancy Congenital xanthoma tuberosum Xanthoma naeviforme Presentation stereotypical Age and sex Y…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…cytic-associated disorders of adults A. Normolipemic cutaneous xanthomatosis 1. Papular 2. Generalized xanthelasma 3. Solitary and eruptive xanthogranuloma 4. Necrobiotic xanthogranuloma 5. Xanthoma disseminatum 6. Subcutaneous xanthomatosis B. Multi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…and scattered interstitially in conjunction with neutrophils = Xanthoma, eruptive + Foamy histiocytes in nodules throughout the dermis and subcutis of volar skin or skin near it = Xanthoma tendinosum and tuberosum + Midreticular dermis of volar s…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…lar dermatosis + 11.24.1B: Foamy histiocytes in a papule = Xanthoma  A xanthoma differs from a xanthogranuloma by being made up of a nearly pure population of foamy histiocytes, practically none of which are multinucleate, and by the absence of a…