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Chapter 1. Acanthosis Nigricans

Definition

Pigmented plaques formed by confluence of smooth-surfaced soft papules, some of which may become polypoid, traversed by accentuations of skin folds. This disease has a predilection for intertriginous regions. The condition may develop consequent to obesity, an endocrine disorder, or a malignant neoplasm in an internal organ. Morphologically, i.e., clinically and histopathologically, the appearance of the altered skin is the same, irrespective of cause.

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