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Chapter 22. Drug Eruptions | Fixed Drug Eruption

Definition

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the genitalia, perioral region, and hands, in response to systemic administration of a particular drug or chemical, chief among them barbiturates and sulfonamides. It is the only type of drug eruption that can be diagnosed with surety histopathologically, the findings in it being entirely specific, unlike the situation in drug eruptions of all other kinds.