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< Current issue
Dermatopathology: Practical & Conceptual April - June 1995
>
Searching for Diogenes: Bulge-Activation Hypothesis Part II—The Bulge is Not a Bulge
Michael Radonich
Cosimo Misciali, MD
A. Bernard Ackerman, MD
Introduction
1876 Unna
1877 Schulin
1883 Unna
1892 Garcia
1904 Stöhr
1927 Felix Pinkus
1935 Zimmermann
1951 Hermann Pinkus
1958 Hermann Pinkus
1961 Sanderson & Thiede
1961 Sanderson
1964 Madsen
1964 Montagna
1984 Headington
1986 Mehregan
1987 Headington & Astle
1990 Leshin & White
1990 Cotsarelis, Sun, Lavker
1991 Sun, Cotsarelis, Lavker
1991 Lavker, Cotsarelis, Wei, Sun
1991 Lane, Wilson, Hughes, Leigh
1992 Jaworsky, Kligman, Murphy
1993 Yang, Lavker, Sun
1993 Lavker, Miller, Wilson, Costarelis, Wei, Yang, Sun
1993 Headington
1993 Whiting
1993 Kobayashi, Rochat, Barrandon
1994 Rochat, Kobayashi, Barrandon
References
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1877 Schulin
Beiträge zur Histologie der Haare. Zeitschrift f Anatomic Entwick Bd II. Leipzig: von F.C.W. Vogel, 1877:375-410 (
Fig. 2
).
View Figure
Fig. 2 [Fig. 4] Anlage of a hair from the temporal scalp of a 18-cm-long human fetus. 1/150. b = the developing papilla; c. = anlage of the sebaceous gland; d = secondary anlage of a hair; e. = protuberance corresponding to the insertion of the m. arrector pili (Unna"s bulge); f. = m. arrector pili. (Reproduced with permission.)
Message
"The bulge" plays no role in the follicular cycle, contrary to the opinion of Unna.
"The bulge" is simply the site for insertion of the muscle of hair erection, and it becomes protuberant as a consequence of the tug of a muscle upon it.
Critique
Schulin denies the hypothesis that "the bulge" is requisite for the follicular cycle.
Schulin did not realize that "the bulge" encircled a follicle; his drawings depict it as being unilateral. This misperception prompted his erroneous conclusion that "the bulge" came into being consequent to the pull of a muscle on the outer sheath.
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