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Dermatopathology: Practical & Conceptual April - June 1995
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Searching for Diogenes: Bulge-Activation Hypothesis Part II—The Bulge is Not a Bulge
Michael Radonich
Cosimo Misciali, MD
A. Bernard Ackerman, MD
Introduction
1876 Unna
1877 Schulin
1883 Unna
1892 Garcia
1904 Stöhr
1927 Felix Pinkus
1935 Zimmermann
1951 Hermann Pinkus
1958 Hermann Pinkus
1961 Sanderson & Thiede
1961 Sanderson
1964 Madsen
1964 Montagna
1984 Headington
1986 Mehregan
1987 Headington & Astle
1990 Leshin & White
1990 Cotsarelis, Sun, Lavker
1991 Sun, Cotsarelis, Lavker
1991 Lavker, Cotsarelis, Wei, Sun
1991 Lane, Wilson, Hughes, Leigh
1992 Jaworsky, Kligman, Murphy
1993 Yang, Lavker, Sun
1993 Lavker, Miller, Wilson, Costarelis, Wei, Yang, Sun
1993 Headington
1993 Whiting
1993 Kobayashi, Rochat, Barrandon
1994 Rochat, Kobayashi, Barrandon
References
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1991 Lavker, Cotsarelis, Wei, Sun
Stem cells of pelage, vibrissae and eyelash follicles: the hair cycle and tumor formation. Ann NY Acad Sci. 1991;642:214—25.
Message
Bulge stem cells in mouse follicles may be pluripotential, i.e., responsible not only for development of the follicle, but for sebaceous glands and epidermis, too.
Critique
Sebaceous units, i.e., lobules and ducts, derive from mantle epithelium that emanates from the junction of infundibulum and isthmus at some distance from "the bulge."
Epidermal epithelium is reconstituted after loss of it from epithelial cells contributed by the upper portion of follicles, i.e., infundibula and eccrine ducts. Eccrine ducts and infundibula are unassociated with bulges.
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