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Dermatopathology: Practical & Conceptual April - June 1995
>
Searching for Diogenes: Bulge-Activation Hypothesis Part II—The Bulge is Not a Bulge
Michael Radonich
Cosimo Misciali, MD
A. Bernard Ackerman, MD
Introduction
1876 Unna
1877 Schulin
1883 Unna
1892 Garcia
1904 Stöhr
1927 Felix Pinkus
1935 Zimmermann
1951 Hermann Pinkus
1958 Hermann Pinkus
1961 Sanderson & Thiede
1961 Sanderson
1964 Madsen
1964 Montagna
1984 Headington
1986 Mehregan
1987 Headington & Astle
1990 Leshin & White
1990 Cotsarelis, Sun, Lavker
1991 Sun, Cotsarelis, Lavker
1991 Lavker, Cotsarelis, Wei, Sun
1991 Lane, Wilson, Hughes, Leigh
1992 Jaworsky, Kligman, Murphy
1993 Yang, Lavker, Sun
1993 Lavker, Miller, Wilson, Costarelis, Wei, Yang, Sun
1993 Headington
1993 Whiting
1993 Kobayashi, Rochat, Barrandon
1994 Rochat, Kobayashi, Barrandon
References
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1993 Kobayashi, Rochat, Barrandon
Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.
Proc Natl Acad Sci USA. 1993;90:7391-5.
Message
Studies of the ability of keratinocytes to form colonies confirm the idea that "the bulge" is the reservoir of stem cells in murine follicles.
Critique
Mice have no bulges, only an equivalent of an isthmus.
Even if stem cells of murine follicles are located in "the bulge," that is not necessarily true for human follicles.
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