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Dermatopathology: Practical & Conceptual January - March 1996
Searching for Diogenes: Uncloaking the Mantle
Martin Sangueza, MD
Michael Anthony Radonich, MD
A. Bernard Ackerman, MD
1876 Unna P
1889 Kölliker A
1895 Benda C
1897 Pinkus F
1902 Hertwig O
1927 Pinkus F
1935 Zimmermann KW
1956 Epstein W, Kligman AM
1963 Strauss JS, Pochi PE
1964 Madsen A
1971 Pinkus H
1972 Hegedus SL, Schorr WF
1976 Pinkus H and Mehregan AH
1987 Ishikawa K
1990 Leshin B, White WL
1991 Mehregan A, Hashimoto K
1992 Jakubovic H, Ackerman AB
1992 Montagna W, Kligman AM, Carlisle KS
1993 Narisawa Y, Hashimoto K, Kobda H
1993 Ackerman AB, deViragh P, and Chongchitnant N
1993 Steffen C
1994 Steffen C, Ackerman AB
1995 Mehregan AH, Hashimoto K, Mehregan DA, Mehregan DR
1995 deViragh PA
1996 Ackerman AB (
1902 Hertwig O
Die Entwicklung der Haut und ihrer Nebenorgane. Lehrbuch der Entwicklungsgeschichte des Menschen und der Wirbeltiere. Jena: Fischer, 1902;7:547566 (
Fig. 4 A, Development of the papilla on the skin surface. B,C,D, Three different phases of hair development in human embryos. td, Sebaceous gland.
Sebaceous glands develop either directly from the epidermis or from solid thickenings of the outer sheath of the follicle. These bottle-shaped thickenings then produce single lateral sprouts that expand at their periphery.
Hertwig described what he interpreted to be the development of the sebaceous gland in its entirety, beginning with a protuberance of the embryonal follicle, progression of that protuberance into a mantle, and eventuation of a mantle into sebaceous cells that in aggregate develop sac-like ends, i.e., lobules.
Sebaceous glands do not develop directly from the epidermis.
The mantle is continuous with the follicle at the junction of the infundibulum and outer sheath at the isthmus, the precise site of the intermediate bulge in an embryo.
Hertwig did not realize that the single lateral sprouts which he observed were actually the mantle described by Pinkus as seen in longitudinal section.
Hertwig seems to have been the first to appreciate the fact that mantles follow formation of sebaceous lobules in embryonic life and later give rise to sebaceous lobules anew.
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