1963 Strauss JS, Pochi PE

 
The hormonal control of human sebaceous glands. In Montagna W, Ellis RA, Silver AF (eds): Advances in Biology of the Skin. New York: MacMillan, 1963. Vol 4: The Sebaceous Gland, pp 220–254 (Fig. 8).

View Figure  		Fig. 8   (orig. Fig. 9). Enlargement of the sebaceous glands of a prepubertal male given 60 mg of hydrocortisone daily. (A) Control biopsy specimen from the cheek with tiny outpocketing of undifferentiated gland cells, as previously shown. (B) Glandular hyperplasia after 8 weeks of hormone administration. (C) Glandular hyperplasia after 12 weeks of hydrocortisone. All sections at the same magnification. (Hematoxylin and eosin, 3 150.) (From Strauss and Kligman, 1959, reproduced with permission of the editors and publishers.)
 

Message

 
An undifferentiated mantle in a pre-pubescent could be induced to become a fully formed sebaceous gland by administering hydrocortisone systemically.
 

Critique

 
This observation was the first indication that undifferentiated mantles were present in skin prior to puberty and that those structures could be both primordial, as well as vestigial, sebaceous glands.