1964 Madsen A

 
Studies on the 'bulge' (Wulst) in superficial basal cell epitheliomas. Arch Dermatol 1964;89:698–708 (Fig. 9).

View Figure  		Fig. 9  (orig. Fig. 9). Digitiform epithelial proliferation with a few lipidized cells. Gland anlage attached to the periphery of the duct wall, enclosing the upper part of the sebaceous gland.
 

Message

 
The anlage of a sebaceous gland may originate from the bulge or from epithelial collars, i.e., buds that contain a few lipidized cells and that are situated above "the bulge."
 
The sebaceous gland undergoes a cycle synchronous with the cycle of the follicle.
 

Critique

 
"The bulge" is a distinct structure unrelated to the anlage of a sebaceous gland. Bulges are protrusions of isthmic epithelium that serve as sites of attachment for muscles of hair erection.
 
The epithelial collars, i.e., buds that contain some lipidized cells, are mantles and are unrelated to bulges.
 
Sebaceous glands undergo a cycle, but it is independent of the follicular cycle. The cycle of sebaceous glands occurs only twice in a human life beginning with involution of sebaceous glands into mantles in the weeks after birth: development of sebaceous glands from mantles at puberty and regression into mantles at menopause/andropause.