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Dermatopathology: Practical & Conceptual January - March 1996
Searching for Diogenes: Uncloaking the Mantle
Martin Sangueza, MD
Michael Anthony Radonich, MD
A. Bernard Ackerman, MD
1876 Unna P
1889 Kölliker A
1895 Benda C
1897 Pinkus F
1902 Hertwig O
1927 Pinkus F
1935 Zimmermann KW
1956 Epstein W, Kligman AM
1963 Strauss JS, Pochi PE
1964 Madsen A
1971 Pinkus H
1972 Hegedus SL, Schorr WF
1976 Pinkus H and Mehregan AH
1987 Ishikawa K
1990 Leshin B, White WL
1991 Mehregan A, Hashimoto K
1992 Jakubovic H, Ackerman AB
1992 Montagna W, Kligman AM, Carlisle KS
1993 Narisawa Y, Hashimoto K, Kobda H
1993 Ackerman AB, deViragh P, and Chongchitnant N
1993 Steffen C
1994 Steffen C, Ackerman AB
1995 Mehregan AH, Hashimoto K, Mehregan DA, Mehregan DR
1995 deViragh PA
1996 Ackerman AB (
1964 Madsen A
Studies on the 'bulge' (Wulst) in superficial basal cell epitheliomas. Arch Dermatol 1964;89:698708 (
Fig. 9 (orig. Fig. 9). Digitiform epithelial proliferation with a few lipidized cells. Gland anlage attached to the periphery of the duct wall, enclosing the upper part of the sebaceous gland.
The anlage of a sebaceous gland may originate from the bulge or from epithelial collars, i.e., buds that contain a few lipidized cells and that are situated above "the bulge."
The sebaceous gland undergoes a cycle synchronous with the cycle of the follicle.
"The bulge" is a distinct structure unrelated to the anlage of a sebaceous gland. Bulges are protrusions of isthmic epithelium that serve as sites of attachment for muscles of hair erection.
The epithelial collars, i.e., buds that contain some lipidized cells, are mantles and are unrelated to bulges.
Sebaceous glands undergo a cycle, but it is independent of the follicular cycle. The cycle of sebaceous glands occurs only twice in a human life beginning with involution of sebaceous glands into mantles in the weeks after birth: development of sebaceous glands from mantles at puberty and regression into mantles at menopause/andropause.
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