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< Current issue
Dermatopathology: Practical & Conceptual January - March 1996
>
Searching for Diogenes: Uncloaking the Mantle
Martin Sangueza, MD
Michael Anthony Radonich, MD
A. Bernard Ackerman, MD
Introduction
1876 Unna P
1889 Kölliker A
1895 Benda C
1897 Pinkus F
1902 Hertwig O
1927 Pinkus F
1935 Zimmermann KW
1956 Epstein W, Kligman AM
1963 Strauss JS, Pochi PE
1964 Madsen A
1971 Pinkus H
1972 Hegedus SL, Schorr WF
1976 Pinkus H and Mehregan AH
1987 Ishikawa K
1990 Leshin B, White WL
1991 Mehregan A, Hashimoto K
1992 Jakubovic H, Ackerman AB
1992 Montagna W, Kligman AM, Carlisle KS
1993 Narisawa Y, Hashimoto K, Kobda H
1993 Ackerman AB, deViragh P, and Chongchitnant N
1993 Steffen C
1994 Steffen C, Ackerman AB
1995 Mehregan AH, Hashimoto K, Mehregan DA, Mehregan DR
1995 deViragh PA
1996 Ackerman AB (
Fig. 19
)
SEE ALSO
-
mantle
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1993 Ackerman AB, deViragh P, and Chongchitnant N
Neoplasms with Follicular Differentiation. Philadelphia: Lea & Febiger, 1993 (
Fig. 17
).
View Figure
Fig. 17 (orig. Fig. 146 (AC)). Mantle-oma at an early stage (Fibrofolliculoma). At scanning magnification, individual vellus follicles can be seen to be the center of fibroepithelial changes that are demarcated by clefts. The epithelial component consists of mantle-like cords of epithelial cells arranged in imperfect fenestrations; the fibrous component is constituted of ribbons of collagen bundles aligned parallel to one another and perpendicular to cords of epithelial cells. The stroma is richly fibrocytic and highly vascular. Although most of the epithelial cells within cords and columns of this fibrofolliculoma are undifferentiated, many show signs of sebaceous differentiation in the form of mature sebocytes disposed as solitary units and lobules, and sebaceous ductal structures. Fibrofolliculoma, therefore, is an abnormality of mantle-like structures and their stroma, and represents a stage in the evolution of trichodiscoma.
Message
Fibrofolliculoma is a mantleoma, a hamartoma that consists initially of undifferentiated mantle epithelium arranged in fenestrated pattern; in time, that epithelium differentiates into sebocytes, sebaceous lobules, and sebaceous ducts. The end-stage of the same process, i.e., when stroma predominates over encircling mitt-like sebaceous glands, is designated trichodiscoma.
Fibrofolliculoma and trichodiscoma are different stages of the same hamartomatous condition. One name for it suffices.
Critique
In theory, trichodiscoma could represent an early stage of the hamartoma and fibrofolliculoma a late one.
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