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Dermatopathology: Practical & Conceptual January - March 1997
>
New Concept: Melanocytic Dysplasia, Dysplastic Nevus, and Dysplastic Nevus Syndrome: Myth! Part IV
Daniela Massi, M.D.
Timothy Nielsen, M.D.
A. Bernard Ackerman, M.D.
Introduction
From Seminars in Diagnostic Pathology
1. Terms and Phrases in the Title and the Abstract of the Article in Seminars in Diagnostic Pathology Not Yet Defined in Comprehensible, Repeatable Fashion
2. Critique of Positions of Clark
et al.
Changed Little or Not at All Since 1978
3. Critique of Positions of Clark
et al.
Changed Radically Since 1978
From the British Medical Bulletin
A. Examples of Impenetrable Language
B. Examples of Unsupported Speculations and Dizzying Definitions
C. A Critique of Positions of Clark
et al.
Changed Radically Since 1978
Two Articles by Clark
Summary of our Position Concerning DN and DNS as Elicited by A Series of Questions About Them
Conclusion
References
SEE ALSO
-
clark's nevus
-
melanoma
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A. Examples of Impenetrable Language
1) Clark et al.:
"Foulds defined incipient neoplasia (the precursor state) as a region coextensive with the area of exposure to carcinogenic treatment that has permanent replicable new reactivity or increased capacity for neoplastic development."
2) Clark et al.:
"Whimster viewed the entire human skin as an organ having '...a planned and organized composition built up of initially separate pieces with differing qualities, purposefully chosen and individually placed together so that together they form a picture or pattern, designed to fulfill an intention."
3) Clark et al.:
"Foulds' Rule III. Progression is independent of growth. Progression occurs in latent tumor cells and in tumors whose growth is arrested. Progression without manifest growth may account for long delayed recurrences and metastases."
Critique:
A reader, no matter how intelligent and motivated, cannot grasp the meaning of these sentences so illustrative of garble in so many of the writings authored by Clark and cohorts about tumor progression, melanocytic dysplasia, DN, and DNS.
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