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< Current issue
Dermatopathology: Practical & Conceptual January - March 1997
>
New Concept: Melanocytic Dysplasia, Dysplastic Nevus, and Dysplastic Nevus Syndrome: Myth! Part IV
Daniela Massi, M.D.
Timothy Nielsen, M.D.
A. Bernard Ackerman, M.D.
Introduction
From Seminars in Diagnostic Pathology
1. Terms and Phrases in the Title and the Abstract of the Article in Seminars in Diagnostic Pathology Not Yet Defined in Comprehensible, Repeatable Fashion
2. Critique of Positions of Clark
et al.
Changed Little or Not at All Since 1978
3. Critique of Positions of Clark
et al.
Changed Radically Since 1978
From the British Medical Bulletin
A. Examples of Impenetrable Language
B. Examples of Unsupported Speculations and Dizzying Definitions
C. A Critique of Positions of Clark
et al.
Changed Radically Since 1978
Two Articles by Clark
Summary of our Position Concerning DN and DNS as Elicited by A Series of Questions About Them
Conclusion
References
SEE ALSO
-
clark's nevus
-
melanoma
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References
1. Reimer RR, Clark WH Jr, Green NH, Ainsworth AM, Fraumeni JF Jr. Precursor lesions in familial melanoma: A new genetic preneoplastic syndrome. JAMA 239:7446, 1978.
2. Greene MH, Reimer RR, Clark WH Jr, Mastrangelo MJ. Precursor lesions in familial melanoma. Semin Oncol 5:857, 1978.
3. Clark WH Jr, Reimer RR, Greene MH, Ainsworth AM, Mastangelo MJ. Origin of Familial Malignant Melanomas from Heritable Melanocytic lesions: The B-K Mole Syndrome. Arch Dermatol 114:7328, 1978.
4. Clark WH Jr, Elder DE, Guerry D IV, Epstein MN, Greene MH, Van Horn M. A study of tumor progression: The pre- cursor lesions of superficial spreading and nodular melanoma. Hum Pathol 15:114765, 1984.
5. Ackerman AB. Melanocytic proliferations that simulate malignant melanoma histopathologically. In Mihm MC Jr, Murphy GF, Kaufman N (eds.) Pathobiology and recognition of malignant melanoma. Williams & Wilkins, Baltimore, 1988:15373.
6. Ackerman AB, Briggs PL, Bravo F. Dysplastic nevus, Compound type vs. Clark's Nevus, Compound type. In Differential Diagnosis in Dermatopathology III. Lea & Febiger, Philadelphia, 1993:15861.
7. National Institutes of Health Consensus Development Conference. Precursors to malignant melanoma. Am J Dermatopathol 6(suppl):16974, 1984.
8. National Institutes of Health Consensus Development Conference. Diagnosis and treatment of early melanoma. JAMA 268:13149, 1992.
9. Green MH, Clark WH Jr, Tucker MA, Elder DE, Kraemer KH, Fraser MC, Bondi EE, Guerry D, Tuthill R, Hamilton R, LaRossa D. Precursor naevi in cutaneous malignant melanoma: A proposed nomenclature. Lancet 2:1024, 1980.
10. Elder DE, Goldman LI, Goldman SC, Greene MH, Clark WH Jr. Dysplastic Nevus Syndrome: A Phenotypic Association of Sporadic Cutaneous Melanoma. Cancer 46:178794, 1980.
11. Ackerman AB, Cavegn BM, Abad-Casintahan F, Robinson MJ. Dysplasia? In Resolving Quandaries in Dermatopathology, Pathology and Dermatopathology. Williams & Wilkins, Baltimore, 1995:858:
12. Rosai J. Ackerman's Surgical Pathology. 8th ed. Mosby, St. Louis, Missouri, 1996.
13. Tavassoli FA. Pathology of the breast. Appleton & Lange, Norwalk, Connecticut, 1992.
14. Clark WH Jr. Malignant melanoma in situ. Hum Pathol 21(12):11978, 1990.
15. Clark WH Jr, Ackerman AB. An exchange of view regarding the dysplastic nevus controversy. Semin Dermatol 8(4):22950, 1989.
16. Greene MH, Goldin LR, Clark WH Jr, Lovrien E, Kraemer KH, Tucker MA,
et al.
Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus. Proc Natl Acad Sci USA 80:60715, 1983.
17. Bale SJ, Dracopoli NC, Tucker MA, Clark WH Jr, Fraser MC, Stanger BZ,
et al.
N Engl J Med 320:136772, 1989.
18. Cannon-Albright LA, Goldgar DE, Wright EC, Turco A, Jost M, Meyer LJ,
et al.
Evidence against the reported linkage of melanoma-dysplastic nevus syndrome locus to 1p36. Am J Hum Genet 46:9128, 1990.
19. Nancarrow DJ, Palmer JM, Walters MK, Kerr BM, Hafner GJ, Garske L,
et al.
Exclusion of the familial melanoma locus (MLM) from the PND/DIS47 and MYCL1 region of chromosome 1p in 7 Australian pedigrees. Genomics 12:1825, 1992.
20. Goldstein AM, Dracopoli NC, Ho EC, Fraser MC, Kearns KS, Bale SJ,
et al.
Further evidence for a locus for cutaneous malignant melanoma-dysplastic nevus (CMM/DN) on chromosome 1p, and evidence for genetic heterogeneity. Am J Hum Genet 52:53750, 1993.
21. Goldstein AM, Dracopoli NC, Engelstein M, Fraser MC, Clark WH Jr, Tucker MA. Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity. Am J Hum Genet 54:48996, 1994.
22. Van Scott EJ and Reinertson RT. The modulating influence of stromal environment on epithelial cells studied in human autotransplants. J Invest Dermatol 36:109131, 1961.
23. Ackerman AB. Persistent lentiginous melanocytic hyperplasia, atypical melanocytic hyperplasia, lamellar fibroplasia, concentric fibroplasia, and lymphocytes as criteria for histopathologic diagnosis of dysplastic nevi? In Resolving Quandaries in Dermatology, Pathology, and Dermatopathology, Williams & Wilkins, Baltimore, 1995:235238.
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