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< Current issue
Dermatopathology: Practical & Conceptual January - March 2001
>
Evolution In Thinking: Criteria for Histopathologic Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Introduction
Becker and Obermayer
Ormsby and Montgomery
Lever
Allen
Percival, Montgomery, and Dodds
Montgomery
Pinkus and Mehregan
Wayte
Clark and Mihm
Milne
Smith
Sanderson
Smith
Price, Rywlin, and Ackerman
Pinkus and Mehregan
Ackerman and Su
Kamino and Ackerman
Domonkos, Arnold, and Odom
Roses, Harris, and Ackerman
MacKie
Okun, Edelstein, and Fisher
McCarthy
et al.
Clark
Kirkham
Weedon and Strutton
Fitzpatrick
et al.
Murphy
Mehregan
et al.
Weedon
Elder and Elenitsas
Barnhill
Langley, Fitzpatrick, and Sober
Langley
et al.
Maize
et al.
Dewan and Ackerman
Farmer and Hood
Conclusion
SEE ALSO
-
melanoma
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Milne
"The term melanocarcinoma is preferred to the more common term malignant melanoma so that there cannot be any possible confusion with benign lesions such as the juvenile melanoma.
There are a number of histologic criteria which offer considerable help. These are:
The upward infiltration of the epidermis by abnormal melanocytes.
The size of the melanocytic nuclei.
The presence of an inflammatory process in the papillary dermis . . . "
Milne JA.
An Introduction to the diagnostic histopathology of the skin
. Baltimore: Williams and Wilkins, 1972:308.
Brief Critique
The three findings said by Milne to be of considerable help in diagnosis of melanoma are expected findings in many examples of Spitz's nevus. As has been stated already, melanocytes are non-epithelial and, therefore, melanoma is a sarcoma, not a carcinoma.
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