Store
|
Contributing Editors
|
Help
|
Contact
|
Sign In
select
All
Images Only
Search
home
resources
images
handouts
videos
quizzes
boardreview
atoz
< Current issue
Dermatopathology: Practical & Conceptual January - March 2001
>
Evolution In Thinking: Criteria for Histopathologic Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Introduction
Becker and Obermayer
Ormsby and Montgomery
Lever
Allen
Percival, Montgomery, and Dodds
Montgomery
Pinkus and Mehregan
Wayte
Clark and Mihm
Milne
Smith
Sanderson
Smith
Price, Rywlin, and Ackerman
Pinkus and Mehregan
Ackerman and Su
Kamino and Ackerman
Domonkos, Arnold, and Odom
Roses, Harris, and Ackerman
MacKie
Okun, Edelstein, and Fisher
McCarthy
et al.
Clark
Kirkham
Weedon and Strutton
Fitzpatrick
et al.
Murphy
Mehregan
et al.
Weedon
Elder and Elenitsas
Barnhill
Langley, Fitzpatrick, and Sober
Langley
et al.
Maize
et al.
Dewan and Ackerman
Farmer and Hood
Conclusion
SEE ALSO
-
melanoma
<
Previous
|
Next
>
Clark
"The individual cells [of melanoma
in situ
] are large and epithelioid, and have an abundance of finely divided pigments [sic], giving the cytoplasm a tan, dusty appearance. The nuclei are large and hyperchromatic, and usually about 1.5 to 2 times the diameter of the surrounding keratinocytes. The cells are relatively uniform in relationship to each other; consequently, they are not strikingly pleomorphic. The cells are disposed individually and in nests."
Clark Jr WH. Malignant melanoma in situ.
Hum Pathol
1990; 21:1197.
Brief Critique
Except for reference to "finely divided pigments [sic] giving the cytoplasm [of melanocytes] a tan, dusty appearance," the changes cited do not permit a melanoma
in situ
to be distinguished from some lesions of Spitz's nevus in which abnormal melanocytes are housed entirely within epidermal and adnexal epithelium. The assertion that the melanocytes of melanoma are marked by uniformity and lack of striking pleomorphism, although patently incorrect, will be invoked subsequently, in parrot fashion, by several other authors who wrote about the subject.
<
Previous
|
Next
>
This site is made possible in part by:
Copyright © Derm101.com. All Rights Reserved.