Clark

 
"The individual cells [of melanoma in situ] are large and epithelioid, and have an abundance of finely divided pigments [sic], giving the cytoplasm a tan, dusty appearance. The nuclei are large and hyperchromatic, and usually about 1.5 to 2 times the diameter of the surrounding keratinocytes. The cells are relatively uniform in relationship to each other; consequently, they are not strikingly pleomorphic. The cells are disposed individually and in nests." Clark Jr WH. Malignant melanoma in situ. Hum Pathol 1990; 21:1197.
 

Brief Critique

 
Except for reference to "finely divided pigments [sic] giving the cytoplasm [of melanocytes] a tan, dusty appearance," the changes cited do not permit a melanoma in situ to be distinguished from some lesions of Spitz's nevus in which abnormal melanocytes are housed entirely within epidermal and adnexal epithelium. The assertion that the melanocytes of melanoma are marked by uniformity and lack of striking pleomorphism, although patently incorrect, will be invoked subsequently, in parrot fashion, by several other authors who wrote about the subject.