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Dermatopathology: Practical & Conceptual July - September 2001
Evolution in Thinking: Criteria for Clinical Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Becker and Obermayer
Ormsby and Montgomery
Sulzberger and Wolf
Pillsbury, Shelley, and Kligman
Fitzpatrick and Clark
Lewis and Wheeler
Callen, Stawiski, and Voorhees
Roses, Harris, and Ackerman
Dobson and Abele
Friedman, Rigel, and Kopf
Fitzpatrick, Rhodes, Sober, and Mihm
Koh and Rogers
McCarthy et al.
Mooi WJ and Krausy
Fitzpatrick, Milton, Balch, Shaw, McCarthy, and Sober
National Institutes of Health Consensus Conference
Holzle, Kind, Plewig, and Burgdorf
Marghoob, Slade, Kopf, Rigel, and Friedman
Arndt, Wintroub, Robinson, and LeBoit
Elder and Elenitsas
Maize et al.
Langley, Fitzpatrick, and Sober
Farmer and Hood
Fleischer, Feldman, Katz, and Clayton
Ackerman, Kerl, Sánchez, et al.
"Early malignant melanoma is characterized by a gradually enlarging, deeply pigmented nodule, usually surrounded by erythema. Later the lesion becomes fungating and satellite lesions may appear. Ulceration is a late symptom."
Histopathology of the Skin.
Philadelphia: J.B. Lippincott, 1949:3989.
Early melanoma is not characterized by a deeply pigmented nodule surrounded by erythema; it is a brownish macule. Only after about a decade or more does a melanoma become "fungating" and associated with metastases in the form of "satellite lesions." Ulceration (which is a sign, not a symptom) of a melanoma signals a poor prognosis.
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