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< Current issue
Dermatopathology: Practical & Conceptual July - September 2001
>
Evolution in Thinking: Criteria for Clinical Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Introduction
Becker and Obermayer
Ormsby and Montgomery
Lever
Sulzberger and Wolf
Pillsbury, Shelley, and Kligman
Fitzpatrick and Clark
Lewis and Wheeler
Wayte
Domonkos
Sanderson
Borrie
Clark
Sneddon
Meara
Fry
Sauer
Callen, Stawiski, and Voorhees
Roenigk
Ackerman
McGovern
Roses, Harris, and Ackerman
Dobson and Abele
Ackerman
Ackerman
Friedman, Rigel, and Kopf
Fitzpatrick, Rhodes, Sober, and Mihm
Koh and Rogers
McCarthy et al.
Habif
MacKie
Marks
Mooi WJ and Krausy
Fitzpatrick, Milton, Balch, Shaw, McCarthy, and Sober
National Institutes of Health Consensus Conference
Levine
Holzle, Kind, Plewig, and Burgdorf
Moynihan
Epstein
Marghoob, Slade, Kopf, Rigel, and Friedman
Arndt, Wintroub, Robinson, and LeBoit
Elder and Elenitsas
Barnhill
Maize et al.
Langley, Fitzpatrick, and Sober
Sagebiel
Farmer and Hood
Fleischer, Feldman, Katz, and Clayton
Ackerman, Kerl, Sánchez, et al.
References
SEE ALSO
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melanoma
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Clark
"Any pigmented lesion that can be covered by the unused eraser of an ordinary yellow pencil is likely to be benign or a curable form of malignant melanoma (except for the uncommon nodular melanoma). Concentrate on those lesions larger than the eraser (7 mm)."
Clark WH Jr.
Clinical diagnosis of cutaneous malignant melanoma.
JAMA 1976;236:4845.
Brief critique
The idea that a "pigmented lesion" less than 7 mm in diameter is "benign or a curable form of malignant melanoma" is specious. Nearly always, primary cutaneous melanomas begin as a macule that is much smaller than 7 mm in diameter. Moreover, melanomas, except for those rare examples in prepubescent children, do not evolve in a fashion analogous to Athena springing from the brow of Zeus; they begin as a tiny macule that grows remarkably slowly. Clinicians should not concentrate on pigmented lesions larger than 7 mm, but on ones that are flat of any size, no matter how small or how large. When a melanoma is flat and without signs of regression, it is curable by simple excision.
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