Marks

 
"Table 3.2 Danger signs of melanoma
 
  1. Increase in size of pre-existing mole or development of new pigmented lesion
  2. Irregular outline developing in pre-existing mole or presence of this feature in new pigmented lesion
  3. Irregular degree of pigmentation (variegation) in pre-existing mole or this feature in new pigmented lesion
  4. Irritation, soreness, inflammation, crusting, erosion, bleeding in pre-existing mole or in new pigmented lesion"
 
Marks R. Sun-damaged Skin. United Kingdom: Martin Dunitz Ltd., 1992:55.
 

Brief critique

 
Two of the four "dangerous signs of melanoma," according to Marks, are dependent on history provided by a patient rather than on morphologic observation by a physician, namely, "increase in size" and "irritation, soreness, inflammation . . ." of a pigmented lesion. The crucial findings for identification of melanoma by a patient should be no different than those utilized by a physician. Those signs, by definition, must be morphologic, rather than anecdotal. Terms like "irregular outline" and "irregular degree of pigmentation" are vague and imprecise. By the time that there is "crusting, erosion, bleeding" of a melanoma, the prognosis is markedly unfavorable; metastases probably have occurred.