< Current issue
Dermatopathology: Practical & Conceptual July - September 2001
Evolution in Thinking: Criteria for Clinical Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Becker and Obermayer
Ormsby and Montgomery
Sulzberger and Wolf
Pillsbury, Shelley, and Kligman
Fitzpatrick and Clark
Lewis and Wheeler
Callen, Stawiski, and Voorhees
Roses, Harris, and Ackerman
Dobson and Abele
Friedman, Rigel, and Kopf
Fitzpatrick, Rhodes, Sober, and Mihm
Koh and Rogers
McCarthy et al.
Mooi WJ and Krausy
Fitzpatrick, Milton, Balch, Shaw, McCarthy, and Sober
National Institutes of Health Consensus Conference
Holzle, Kind, Plewig, and Burgdorf
Marghoob, Slade, Kopf, Rigel, and Friedman
Arndt, Wintroub, Robinson, and LeBoit
Elder and Elenitsas
Maize et al.
Langley, Fitzpatrick, and Sober
Farmer and Hood
Fleischer, Feldman, Katz, and Clayton
Ackerman, Kerl, Sánchez, et al.
Maize et al.
"A wide range of clinical appearances can be seen in melanoma. In situ lesions begin as macules with pigmentation that varies from pink to dark brown. If the cells of a melanoma enter the dermis early in the evolution of a lesion, a papule or nodule can form with or without a perceptible flat component. Variation in pigmentation is a hallmark of melanoma. Shades of brown and black are often seen; thick lesions have foci of red, white, or blue on occasion. Large nodules can be ulcerated."
Maize JC, et al.
Philadelphia: Churchill Livingstone, 1998:687.
Maize rightly correlates the histopathologic findings of melanoma
with a macule of melanoma that may vary in color from pink to dark brown. Also correctly, he contrasts macules with large nodules that may be ulcerated. Macules of melanoma are curable by simple excision, whereas large ulcerated nodules often are not because metastases have disseminated from them.
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