Langley, Fitzpatrick, and Sober

 
"Hallmarks of melanoma include (1) variation in color, (2) an irregular, raised surface (although the elevation may at times require side lighting to appreciate), (3) an irregular border with indentations, and (4) ulceration of the surface epithelium."
 
Langley RGB, Fitzpatrick TB, Sober AJ. Clinical Characteristics. In: Balch CM, Houghton AN, Sober AJ, Soong S, (eds.). Cutaneous Melanoma. 3rd Edition. St. Louis: Quality Medical Publishing, Inc., 1998:84.
 

Brief critique

 
The four criteria set forth by Langley, Fitzpatrick, and Sober are even less helpful for diagnosis of very early lesions of melanoma than the ABCDs. In common with the ABCDs is "(1) variegation in color," which is the C of the ABCDs, and (2) "An irregular border with identations" which is the B in the ABCDs. By the time a melanoma has "an irregular, raised surface," there is no assurance it can be cured by simple excision, and by the time there is "ulceration of the surface epithelium," there is little chance for cure; metastasis has already occurred. In short, although neither a nodule nor a tumor is mentioned among these "hallmarks of melanoma," the co-authors continue to trumpet ABCDE, the E standing for elevated. This is poor pedagogy for patients and for physicians who should be instructed about recognizing melanomas at a stage before they have metastasized and, therefore, are curable surgically.