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Dermatopathology: Practical & Conceptual July - September 2001
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Evolution in Thinking: Criteria for Clinical Diagnosis of Melanoma, 1947–2000: A Critique in Historical Perspective
Mary Aldrene L. Tan, M.D.
A. Bernard Ackerman, M.D.
Introduction
Becker and Obermayer
Ormsby and Montgomery
Lever
Sulzberger and Wolf
Pillsbury, Shelley, and Kligman
Fitzpatrick and Clark
Lewis and Wheeler
Wayte
Domonkos
Sanderson
Borrie
Clark
Sneddon
Meara
Fry
Sauer
Callen, Stawiski, and Voorhees
Roenigk
Ackerman
McGovern
Roses, Harris, and Ackerman
Dobson and Abele
Ackerman
Ackerman
Friedman, Rigel, and Kopf
Fitzpatrick, Rhodes, Sober, and Mihm
Koh and Rogers
McCarthy et al.
Habif
MacKie
Marks
Mooi WJ and Krausy
Fitzpatrick, Milton, Balch, Shaw, McCarthy, and Sober
National Institutes of Health Consensus Conference
Levine
Holzle, Kind, Plewig, and Burgdorf
Moynihan
Epstein
Marghoob, Slade, Kopf, Rigel, and Friedman
Arndt, Wintroub, Robinson, and LeBoit
Elder and Elenitsas
Barnhill
Maize et al.
Langley, Fitzpatrick, and Sober
Sagebiel
Farmer and Hood
Fleischer, Feldman, Katz, and Clayton
Ackerman, Kerl, Sánchez, et al.
References
SEE ALSO
-
melanoma
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Langley, Fitzpatrick, and Sober
"Hallmarks of melanoma include (1) variation in color, (2) an irregular, raised surface (although the elevation may at times require side lighting to appreciate), (3) an irregular border with indentations, and (4) ulceration of the surface epithelium."
Langley RGB, Fitzpatrick TB, Sober AJ. Clinical Characteristics. In: Balch CM, Houghton AN, Sober AJ, Soong S, (eds.).
Cutaneous Melanoma.
3rd Edition. St. Louis: Quality Medical Publishing, Inc., 1998:84.
Brief critique
The four criteria set forth by Langley, Fitzpatrick, and Sober are even less helpful for diagnosis of very early lesions of melanoma than the ABCDs. In common with the ABCDs is "(1) variegation in color," which is the C of the ABCDs, and (2) "An irregular border with identations" which is the B in the ABCDs. By the time a melanoma has "an irregular, raised surface," there is no assurance it can be cured by simple excision, and by the time there is "ulceration of the surface epithelium," there is little chance for cure; metastasis has already occurred. In short, although neither a nodule nor a tumor is mentioned among these "hallmarks of melanoma," the co-authors continue to trumpet ABCDE, the E standing for elevated. This is poor pedagogy for patients and for physicians who should be instructed about recognizing melanomas at a stage before they have metastasized and, therefore, are curable surgically.
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