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Dermatopathology: Practical & Conceptual January - March 2002
>
New Concept: Melanomas in Prepubescent Children: Review Comprehensively, Critique Historically, Criteria Diagnostically, and Course Biologically
Joan M. Mones, D.O.
A. Bernard Ackerman, M.D.
Abstract
Definition of “Prepubescent” and of Proven “Melanomas” for Purposes of This Treatise
Historical Perspective: Darier and A. Civatte, 1910
Historical Perspective: Coe, 1925; Pack and Anglem, 1939
Historical Perspective: Pack et al., 1947; L. Ackerman and del Regato, 1947
Historical Perspective: Pack, 1948; MacDonald, 1948
Historical Perspective: Spitz, 1948
Historical Perspective: Allen, 1949
Historical Perspective: Spitz, 1951; Pack and Scharnagel, 1951
Historical Perspective: Truax and Allen, 1953; Allen and Spitz, 1953
Historical Perspective: Becker, 1954; McWhorter and Woolner, 1954
Historical Perspective: McWhorter et al., 1954; Hendrix, 1954; Dobson, 1955
Historical Perspective: Allen, 1960
Historical Perspective: Hoagland and Hughes, 1960
Historical Perspective: Pontius and Dziabis, 1961; McGovern and Goulston, 1963
Historical Perspective: Giersten, 1964; Kopf and Andrade, 1966
Historical Perspective: Responses of Allen to Kopf and Andrade, 1966
Historical Perspective: Skov-Jensen et al., 1966; Zwaveling et al., 1966; Saksela and Rintala, 1968
Historical Perspective: Lerman et al., 1970
Historical Perspective: Trozak et al., 1975; Shanon et al., 1976
Historical Perspective: Helwig, 1975
Historical Perspective: Speculations of Helwig, 1975
Historical Perspective: Boddie, et al., 1978
Historical Perspective: Stomberg, 1979; Pratt et al., 1981
Historical Perspective: Flemming and Ruggins, 1985; Bader et al., 1985
Historical Perspective: Peters and Goellner, 1986
Historical Perspective: Moss and Briggs, 1986; Melnick et al., 1986; Chapman et al., 1987
Historical Perspective: Donner et al., 1988
Historical Perspective: Fisher et al., 1988
Historical Perspective: K. Smith et al., 1989: “Malignant Spitz’s Nevus”
Historical Perspective: Partoff et al., 1989; Roth et al., 1990
Historical Perspective: Allen, 1991
Historical Perspective: Temple et al., 1991
Historical Perspective: Crotty et al., 1992
Historical Perspective: A. H. Mehregan and D. A. Mehregan, 1993
Historical Perspective: Tate et al., 1993
Historical Perspective: Chun et al., 1993; Bartoli et al., 1994; Nitta et al., 1995
Historical Perspective: Barnhill et al., 1995
Historical Perspective: Barnhill et al., 1995: “Metastasizing Spitz’s Tumor”
Historical Perspective: Barnhill et al., 1995: “Atypical Spitz Tumor”
Historical Perspective: Lartigau et al., 1995
Historical Perspective: Whiteman et al., 1995; Handfield-Jones and N. Smith, 1996
Historical Perspective: Spatz et al., 1996; Naasan et al., 1996
Historical Perspective: Scalzo et al., 1997; Eady, 1997; Crotty, 1997; Zhu et al., 1997
Historical Perspective: Wu and Lambert, 1997; Milton et al., 1997
Historical Perspective: Spatz and Avril, 1998
Historical Perspective: Barnhill, 1998; Spatz and Barnhill, 1999
Historical Perspective: Barnhill et al., 1999
Historical Perspective: Rapini, 1999
Historical Perspective: Strojan and Lamovec, 2000; Davis, 2000; Neville et al., 2000
Historical Perspective: Kogut et al., 2000; Patterson et al., 2000; Zuckerman et al., 2001
Historical Perspective: Conti et al., 2001; Fabrizi and Massi, 2001
Summary: Major Sources of Error in Interpretation
Summary: Major Errors of Pack, Spitz, and Allen
Summary: Major errors of Helwig, K. Smith, and Barnhill
Our Experience
Clinical Appearance
Histopathologic Findings (
Figure 18
)
Histopathologic Findings (
Figure 19
)
Histopathologic Findings (
Figure 20
)
Histopathologic Findings (
Figure 21
)
Histopathologic Findings (
Figure 22
)
Histopathologic Findings (
Figure 23
)
Histopathologic Findings (
Figure 24
)
Histopathologic Findings (
Figure 25
)
Differences Histopathologically Between Melanomas in Prepubescents and in Postpubescents: Scanning Magnification
Differences Histopathologically Between Melanomas in Prepubescents and Postpubescents: Higher Magnification
Histopathologic Differential Diagnosis
Biologic Behavior
Synthesis
Purpose of This Endeavor and the Essence of the Message
Conclusions
Addendum and Caveat
Postscript
Acknowledgements
References
SEE ALSO
-
melanoma
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Historical Perspective: Stomberg, 1979; Pratt et al., 1981
In 1979, Stomberg
32
reported on six children who had been seen during an 18-year period at Case Western Reserve University Hospitals. Two of the melanomas were said to have been present since birth, one in association with a giant nevus (the melanoma extended from the temporal region through the dura) and the other in what otherwise seemed to be normal skin of the left mastoid process of a 4-month-old infant (it metastasized to retroauricular lymph nodes). Of the four melanomas that developed after birth and apparently
de novo,
one occurred on the pinna of the left ear of a 9-year-old girl and subsequently metastasized to cervical lymph nodes; a second was on the back of a 12-year-old boy and it, too, gave rise to metastasis; the third was a 2 mm melanotic nodule that occurred on the upper left eyelid of a 14-year-old black girl, and the last was on the lateral right upper arm of a 14-year-old boy. The14-year-olds had no evidence of metastatic disease after follow-up of 13 years and two years, respectively. Stomberg never defined precisely what he meant by "prepubertal," but one may infer that he meant 14 years of age and younger. Stromberg stated that
"the cases presented have satisfied the strict pathological criteria for malignant melanoma,"
but he showed no photomicrographs to reinforce that assertion. In his judgment,
"prognosis [for persons with prepubertal malignant melanoma] does not differ markedly from similar lesions in adults."
Under the title, "Malignant melanoma in children and adolescents," Pratt and associates,
33
in 1981, detailed the clinical features of melanoma in 31 patients who were less than 21 years of age. No photomicrographs were shown, but Pratt et al. commented tersely on the histopathological findings in those neoplasms thus:
"The pathologic findings of 31 patients satisfied the criteria for the diagnosis of malignant melanoma by virtue of characteristics including melanin-producing polymorphic malignant cells with increased number of mitotic figures and invasion of deeper tissues."
Those changes, presented somewhat vaguely, are not distinguishing from findings in some examples of Spitz's nevus (benign juvenile melanoma, spindle and epithelioid cell nevus). With respect to survival, Pratt and co-workers made these observations:
"Median survival for the group of 31 patients is about eight years. Median disease-free interval, however, was only 20 months. . . . Survival was also examined in relation to the anatomic location of the primary, presence or absence of pre-existing skin lesions, and age at diagnosis (above or below 12 years). None of these factors was statistically significant predictions of survival."
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