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Dermatopathology: Practical & Conceptual January - March 2002
>
New Concept: Melanomas in Prepubescent Children: Review Comprehensively, Critique Historically, Criteria Diagnostically, and Course Biologically
Joan M. Mones, D.O.
A. Bernard Ackerman, M.D.
Abstract
Definition of “Prepubescent” and of Proven “Melanomas” for Purposes of This Treatise
Historical Perspective: Darier and A. Civatte, 1910
Historical Perspective: Coe, 1925; Pack and Anglem, 1939
Historical Perspective: Pack et al., 1947; L. Ackerman and del Regato, 1947
Historical Perspective: Pack, 1948; MacDonald, 1948
Historical Perspective: Spitz, 1948
Historical Perspective: Allen, 1949
Historical Perspective: Spitz, 1951; Pack and Scharnagel, 1951
Historical Perspective: Truax and Allen, 1953; Allen and Spitz, 1953
Historical Perspective: Becker, 1954; McWhorter and Woolner, 1954
Historical Perspective: McWhorter et al., 1954; Hendrix, 1954; Dobson, 1955
Historical Perspective: Allen, 1960
Historical Perspective: Hoagland and Hughes, 1960
Historical Perspective: Pontius and Dziabis, 1961; McGovern and Goulston, 1963
Historical Perspective: Giersten, 1964; Kopf and Andrade, 1966
Historical Perspective: Responses of Allen to Kopf and Andrade, 1966
Historical Perspective: Skov-Jensen et al., 1966; Zwaveling et al., 1966; Saksela and Rintala, 1968
Historical Perspective: Lerman et al., 1970
Historical Perspective: Trozak et al., 1975; Shanon et al., 1976
Historical Perspective: Helwig, 1975
Historical Perspective: Speculations of Helwig, 1975
Historical Perspective: Boddie, et al., 1978
Historical Perspective: Stomberg, 1979; Pratt et al., 1981
Historical Perspective: Flemming and Ruggins, 1985; Bader et al., 1985
Historical Perspective: Peters and Goellner, 1986
Historical Perspective: Moss and Briggs, 1986; Melnick et al., 1986; Chapman et al., 1987
Historical Perspective: Donner et al., 1988
Historical Perspective: Fisher et al., 1988
Historical Perspective: K. Smith et al., 1989: “Malignant Spitz’s Nevus”
Historical Perspective: Partoff et al., 1989; Roth et al., 1990
Historical Perspective: Allen, 1991
Historical Perspective: Temple et al., 1991
Historical Perspective: Crotty et al., 1992
Historical Perspective: A. H. Mehregan and D. A. Mehregan, 1993
Historical Perspective: Tate et al., 1993
Historical Perspective: Chun et al., 1993; Bartoli et al., 1994; Nitta et al., 1995
Historical Perspective: Barnhill et al., 1995
Historical Perspective: Barnhill et al., 1995: “Metastasizing Spitz’s Tumor”
Historical Perspective: Barnhill et al., 1995: “Atypical Spitz Tumor”
Historical Perspective: Lartigau et al., 1995
Historical Perspective: Whiteman et al., 1995; Handfield-Jones and N. Smith, 1996
Historical Perspective: Spatz et al., 1996; Naasan et al., 1996
Historical Perspective: Scalzo et al., 1997; Eady, 1997; Crotty, 1997; Zhu et al., 1997
Historical Perspective: Wu and Lambert, 1997; Milton et al., 1997
Historical Perspective: Spatz and Avril, 1998
Historical Perspective: Barnhill, 1998; Spatz and Barnhill, 1999
Historical Perspective: Barnhill et al., 1999
Historical Perspective: Rapini, 1999
Historical Perspective: Strojan and Lamovec, 2000; Davis, 2000; Neville et al., 2000
Historical Perspective: Kogut et al., 2000; Patterson et al., 2000; Zuckerman et al., 2001
Historical Perspective: Conti et al., 2001; Fabrizi and Massi, 2001
Summary: Major Sources of Error in Interpretation
Summary: Major Errors of Pack, Spitz, and Allen
Summary: Major errors of Helwig, K. Smith, and Barnhill
Our Experience
Clinical Appearance
Histopathologic Findings (
Figure 18
)
Histopathologic Findings (
Figure 19
)
Histopathologic Findings (
Figure 20
)
Histopathologic Findings (
Figure 21
)
Histopathologic Findings (
Figure 22
)
Histopathologic Findings (
Figure 23
)
Histopathologic Findings (
Figure 24
)
Histopathologic Findings (
Figure 25
)
Differences Histopathologically Between Melanomas in Prepubescents and in Postpubescents: Scanning Magnification
Differences Histopathologically Between Melanomas in Prepubescents and Postpubescents: Higher Magnification
Histopathologic Differential Diagnosis
Biologic Behavior
Synthesis
Purpose of This Endeavor and the Essence of the Message
Conclusions
Addendum and Caveat
Postscript
Acknowledgements
References
SEE ALSO
-
melanoma
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Historical Perspective: Partoff et al., 1989; Roth et al., 1990
In 1989, Partoff and associates
43
wrote of their attempt to determine the incidence of melanoma in children 14 years old and younger who were enrolled in the Danish Cancer Registry between 1943 and 1982. Although medical records and tissue sections were not available for review, Partoff et al. were able to identify nine such patients. This is some of what they wrote about them:
"In conclusion, we were able to identify nine cases of childhood melanoma in Denmark. . . . Two of the melanomas had developed before puberty and the remaining seven around onset of puberty. Two of the tumors developed in congenital great naevi. Not surprisingly, we find that childhood melanomas have been gravely overdiagnosed in Denmark in the past 40 years, especially before 1958. The stable incidence of childhood melanomas observed over the 40-year period is in sharp contrast with the rapid increase in incidence of skin melanomas in adults."
In a work published in 1990 under the title, "Melanoma in children," Roth and colleagues,
45
reported on melanoma in four children aged 16, 4, 12, and 15 (their cases 1 through 4, respectively). In three of those children, the melanoma supposedly arose in a pre-existing nevus. A 16-year-old girl (Case 1) had a melanoma that apparently began
de novo
on the left flank and was described as being "nodular or polypoid type," at least 2.0 mm in thickness. She subsequently developed signs of metastases to lymph nodes and to bone, and died 11 months later. Three photomicrographs of that melanoma were shown, but only at high magnification. A 4-year-old girl (Case 2) had a "superficial spreading melanoma," 0.52 mm thick on the left thigh. No photomicrographs were published and no comment was made about whether or not the melanoma was present in conjunction with a nevus, but Roth and coworkers claimed nonetheless that the melanoma was congenital. No metastasis had become manifest by the time the article was in print. A 12-year-old girl (Case 3) with multiple nevi had excised from her back what was thought to be melanoma
in situ
and therefore was free of any sign of metastatic disease. A melanoma that measured 0.35 mm in thickness was excised from the right scapula of a 15-year-old boy (Case 4) who had "several dysplastic nevi." He seemed to be free of metastases. Based on their observations of these four patients, Roth and coworkers summarized their thoughts as follows:
"In children, as in adults, the depth of invasion of the primary tumor [of malignant melanoma] correlates well with prognosis. That children with thin tumors have a better prognosis than those with thick lesions emphasizes the importance of early diagnosis of melanoma in children . . ."
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