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Dermatopathology: Practical & Conceptual July - September 2002
Prurigo Pigmentosa: New Observations and Comprehensive Review
Almut Böer, M.D.
Noriyuki Misago, M.D.
Manfred Wolter, M.D.
Hiromaro Kiryu, M.D.
Xiao Dong Wang, M.D.
A. Bernard Ackerman, M.D.
Differential Diagnosis Clinically
Differential Diagnosis Histopathologically
Fourteen of the Japanese patients responded well to minocycline (100 to 200 mg daily); the German woman did, too. Seven of the Japanese patients were treated with dapsone, 25 mg daily, with good effect. The eruption in a 18-year-old Japanese woman and in a 32-year-old Japanese man recurred in two years, but then responded favorably once again to minocycline. The lesions in the Turkish woman became quiescent after administration of dapsone, but that medication had to be stopped because of side effects hematologically. Treatment then with 200 mg minocycline daily was sufficient to halt the eruption; the papules resolved and no new ones appeared. When treatment was discontinued, however, new lesions erupted within a week.
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