In a series of brochures printed between 1962 and 1965, the American Joint Committee on Cancer (AJCC) Staging and End Results Reporting applied the TNM staging system to breast carcinoma, laryngeal carcinoma, and to various forms of gynecological carcinoma,⁶ TNM standing for Tumor size (T), Nodal status (N), and distant Metastases (M). These parameters were used to stage individuals with different kinds of cancer. By virtue of the influence of this system, McNeer and Das Gupta of the Memorial Sloan-Kettering Cancer Center applied, in 1964, similar principles to the staging of melanoma. They also proposed a system of three tiers designated Stage I, II, and III, and subclassified each of the tiers as follows: