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Dermatopathology: Practical & Conceptual July - September 2002
>
Flawed Concept: Staging of Melanoma: A Critique in Historical Perspective
Bradley Bakotic, D.O.
A. Bernard Ackerman, M.D.
Abstract
Introduction
Systems of Staging in Chronologic Sequence: L.V. Ackerman and Delgato (1947)
Sylven (1949)
American Joint Committee on Cancer (1962–1965)
McNeer and Das Gupta (1964)
M.D. Anderson Cancer Center (1976)
American Joint Committee on Cancer (1977)
Union Internationale Contre Le Cancer (1978)
American Joint Committee on Cancer (1983)
American Joint Committee on Cancer and Union Internationale Contre le Cancer (1988, 1992, 1997)
American Joint Committee on Cancer (2000, 2001)
“Evolution” in Staging is Paralleled by Devolution in Critical Thought
References
SEE ALSO
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melanoma
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metastatic melanoma
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American Joint Committee on Cancer (1977)
In 1977, the staging system of the AJCC was the first to incorporate "microstaging," that is, findings by conventional microscopy such as Clark's levels and Breslow's thicknesses.
9
Theirs, too, was a four-tier system, although Stage I was divided into IA and IB. The system was formulated in this manner:
Stage IA. Tumor invading papillary dermis but not reticular dermis (levels II and III and < 1.51 mm in thickness)
Stage IB. Tumor invading reticular dermis or subcutaneous tissues (levels IV and V) and > 1.51 mm in thickness
Stage II. Regional lymph node spread or satellites <2cm from the primary lesion
Stage III. Contralateral or bilateral lymph node spread or massive/fixed regional nodes
Stage IV. Distant metastasis
Novel, as well, was the placement of distant lymph node metastases in Stage III. That decision resulted in a system in which three of the four stages were related intimately. In short, Stages II, III, and IV all come into being as a result, directly, of the same initiating event, that is, neoplastic cells of melanoma gaining access to the systemic circulation. Because the lymphatic and hematogenous circulations are connected to one another, metastases, irrespective of whether they are termed satellite, in transit, regional, or distant (including visceral), have in common dissemination through vascular channels of both kinds. In this sense, all metastases, no matter where they first manifest themselves or where they are first detected, are distant conceptually.
10
To complicate matters further, the introduction of notions such as "massive" or "fixed" lymph nodes heightened the subjectivity of the system even more, the likes of which had not been seen since the staging system first was brought forth by Ackerman and Del Regato.
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