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Dermatopathology: Practical & Conceptual April - June 2003
>
Erratum: Proliferating Tricholemmal Cystic Carcinoma (Revision of Chapter XXV of the Volume Titled
Neoplasms with Follicular Differentiation,
2nd edition by Ackerman, Reddy, and Soyer, Ardor Scribendi, Ltd., 2001)
A. Bernard Ackerman M.D.
Joan Mones, D.O.
Abstract
Editor’s Note
Historical Perspective
Features Clinically
Findings Histopathologically
Stereotypical Example of a Proliferating Tricholemmal Cystic Acanthoma
Stereotypical Examples of Proliferating Tricholemmal Cystic Carcinomas
Cytopathologic Attributes of Proliferating Tricholemmal Cystic Carcinoma
Origin of Proliferating Tricholemmal Cystic Carcinoma
Differentiation of Proliferating Tricholemmal Cystic Carcinoma
Problems in Diagnosis of Proliferating Tricholemmal Cystic Carcinoma
Histopathologic Differential Diagnosis
Biologic Behavior
Suppositions about Pathogenesis
Conclusion
Acknowledgements
References
SEE ALSO
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proliferating tricholemmal cystic carcinoma
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Conclusion
The name
proliferating tricholemmal cystic carcinoma
communicates the idea that the neoplasm under scrutiny here is malignant, a carcinoma differentiating toward tricholemmal sheath at the isthmus or of a follicle well advanced in catagen. Where it begins is not known for sure, but it is highly likely that most examples originate in a tricholemmal (isthmic-catagen) cyst. In some instances, proliferating tricholemmal cystic carcinoma probably develops
de novo
from surface and/or infundibular epidermis. Although the term tricholemmal is generic, referring as it does to the entire outer sheath, that is, at the bulb, the stem, and the isthmus, we, unlike Monteagudo,
72
affirm that for the title of the particular kind of carcinoma under discussion here, "tricholemmal" serves.
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