Derm101 | New Heights

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Dermatopathology: Practical & Conceptual October - December 2003 >

New Heights: “Hypopigmented mycosis fungoides” is not always mycosis fungoides!

Betina Werner, M.D.
Sonya Brown, M.D.
A. Bernard Ackerman, M.D.

Introduction

Patient one

Patient 2

The issue of hypopigmentation in mycosis fungoides

Our method for attempting to assess authenticity of a hypopigmented expression of mycosis fungoides

Definition of mycosis fungoides and criteria morphologically (clinical and histopathologic) for diagnosis of it

“Hypopigmented mycosis fungoides” in historical perspective

Our conclusions about “hypopigmented mycosis fungoides”

Summary of attributes of the patients who surely had “hypopigmented mycosis fungoides”

Photographs of clinical lesions and photomicrographs of the 19 patients with unquestionable hypopigmented mycosis fungoides

Summary of attributes of the patients who did not have “hypopigmented mycosis fungoides”

Photographs of clinical lesions and photomicrographs of the four patients who did not have hypopigmented mycosis fungoides:

Reasons we were unable to make a specific diagnosis of mycosis fungoides in some patients reputed to have it

Conclusions in the form of five questions and our own answers to them

How to differentiate, clinically and histopathologically, pityriasis alba and vitiligo from hypopigmented mycosis fungoides

A patient with stereotypical mycosis fungoides associated with hypopigmentation

A patient with stereotypical mycosis fungoides associated with both hypo- and hyperpigmentation

Closing Comment

Acknowledgements

References

SEE ALSO
- mycosis fungoides
- pityriasis alba
- vitiligo

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Photographs of clinical lesions and photomicrographs of the 19 patients with unquestionable hypopigmented mycosis fungoides

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Figs. 10 & 11 Ryan et al.¹

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Figs. 12 & 13 Smith and Samman²

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Figs. 14 & 15 Breathnach et al.³

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Figs. 16 & 17 Rustin et al.⁶

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Figs. 18 & 19 Goldberg et al.⁷

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Fig. 20 Sigal et al.⁹ No image histopathologically was provided by Sigal et al.

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Figs. 21 & 22 Handfield-Jones et al.¹¹

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Figs. 23 & 24 Volkenandt et al.¹²

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Figs. 25 & 26 Lambroza et al.¹⁶ Patient One

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Figs. 27 & 28 Lambroza et al.¹⁶ Patient Two

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Figs. 29 & 30 El-Hoshy et al.¹⁷

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Figs. 31 & 32 Zackheim et al.¹⁹

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Figs. 33 & 34 Di Leandro et al.²⁰

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Figs. 35 & 36 Zucker-Franklin et al.²³

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Figs. 37 & 38 Choe et al.²⁵

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Figs. 39 & 40 Neuhaus et al.²⁹

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Figs. 41 & 42 Stone et al.³² Patient One

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Figs. 43 & 44 Stone et al.³² Patient Two

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Figs. 45 & 46 Ardigo et al.³⁴

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