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Dermatopathology: Practical & Conceptual October - December 2003
>
New Heights: “Hypopigmented mycosis fungoides” is not always mycosis fungoides!
Betina Werner, M.D.
Sonya Brown, M.D.
A. Bernard Ackerman, M.D.
Introduction
Patient one
Patient 2
The issue of hypopigmentation in mycosis fungoides
Our method for attempting to assess authenticity of a hypopigmented expression of mycosis fungoides
Definition of mycosis fungoides and criteria morphologically (clinical and histopathologic) for diagnosis of it
“Hypopigmented mycosis fungoides” in historical perspective
Our conclusions about “hypopigmented mycosis fungoides”
Summary of attributes of the patients who surely had “hypopigmented mycosis fungoides”
Photographs of clinical lesions and photomicrographs of the 19 patients with unquestionable hypopigmented mycosis fungoides
Summary of attributes of the patients who did not have “hypopigmented mycosis fungoides”
Photographs of clinical lesions and photomicrographs of the four patients who did not have hypopigmented mycosis fungoides:
Reasons we were unable to make a specific diagnosis of mycosis fungoides in some patients reputed to have it
Conclusions in the form of five questions and our own answers to them
How to differentiate, clinically and histopathologically, pityriasis alba and vitiligo from hypopigmented mycosis fungoides
A patient with stereotypical mycosis fungoides associated with hypopigmentation
A patient with stereotypical mycosis fungoides associated with both hypo- and hyperpigmentation
Closing Comment
Acknowledgements
References
SEE ALSO
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mycosis fungoides
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pityriasis alba
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vitiligo
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A patient with stereotypical mycosis fungoides associated with both hypo- and hyperpigmentation
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Figs. 59 & 60 Patches, most of them hypopigmented but some of them hyperpigmented.
A 57-year old Hispanic man had discolored patches on the upper and lower limbs for years. Most of the patches were situated on the forearms and the legs, those at the former site being hyperpigmented and those at the latter site both hyper- and hypopigmented, the ones with little pigment being nummular. A biopsy of a representative lesion was performed.
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Figs. 61AI Stereotypical findings of the macular/patch stage of mycosis fungoides.
The findings by microscopy are those of mycosis fungoides, to wit, lymphocytes around venules of the superficial plexus, scattered in some dermal papillae, aligned as solitary units in loci of the epidermal basal layer and disposed in near clusters in foci of the spinous zone in company with paltry spongiosis, above which was a tad of parakeratosis.
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