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Dermatopathology: Practical & Conceptual January - March 2006
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5. New Heights: An assist to the next (10th) edition of “Lever’s”
Renata A. Joffe, M.D.
Content
Introduction
1. Small plaque parapsoriasis
2. Dysplastic nevus
3. Solar keratosis
4. Inverted follicular keratosis/trichilemmoma
5. Discoid lupus erythematosus vs. systemic lupus erythematosus
6. Lentigo maligna
7. Atopic dermatitis
8. Sebaceous adenoma
9. Muir-Torre syndrome
10. Bowen’s disease
11. Follicular mucinosis/alopecia mucinosa
12. Granuloma faciale and erythema elevatum diutinum
13. Follicular degeneration syndrome
14. Eccrine papillary adenoma
15. Degos’ disease
16. Dermatofibroma
17. Proliferating tricholemmal cyst
18. Erythema multiforme (dermal and epidermal types)
19. Lichen sclerosus et atrophicus vs. morphea
20. Malignant melanoma (classification)
21. Malignant melanoma—ABCD’s
22. Malignant melanoma—wide/deep excision
23. Sentinel node biopsy for melanoma
24. Malignant melanoma: nontumorigenic compartment of primary malignant melanoma (radial growth phase), tumorigenic compartment of primary malignant melanoma (vertical growth phase)
25. Minimal deviation melanoma
26. Nevoid melanoma
27. Malignant melanoma—in infancy and childhood
28. Malignant blue nevus
29. MELTUMP and SAMPUS
30. Bulge activation hypothesis
Conclusion
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8. Sebaceous adenoma
Quotation from the 9th edition of Lever's:
"In terms of differentiation, sebaceous adenoma stands between sebaceous hyperplasia, in which sebaceous lobules appear fully or nearly fully matured, and sebaceous epithelioma or sebaceomaSebaceous adenoma and sebaceous epithelioma lack nuclear atypia and invasive, asymmetric growth patterns, which are hallmarks of sebaceous carcinoma."
Reference in the 9th edition to concepts contrary by A. Bernard Ackerman et al. (ABA): None.
Statements contrary by ABA:
"Sebaceous 'Adenoma' is Sebaceous Carcinoma. In short, in our judgment, so-called cystic sebaceous adenoma is really sebaceous carcinoma."
Nussen S, Ackerman AB. Sebaceous "adenoma" is sebaceous carcinoma.
Dermatopathology: Practical & Conceptual
4(1):5-14, 1998.
Other works of ABA in which the ideas contrary are expressed:
1. Muir-Torre Syndrome (video), available at: www.derm101.com, 2005.
2. Ackerman AB, Lee SN. Neoplasms in all organs of Muir-Torre syndrome are carcinomas: sebaceous carcinomas and squamous-cell carcinomas (keratoacanthomas) in skin and adenocarcinomas, squamous-cell carcinomas, and transitional-cell carcinomas in internal organs.
Dermatopathology: Practical & Conceptual
5(4):312-318, 1999.
3. DiLeonardo M, Ackerman AB. Sebaceous carcinoma revisited.
Dermatopathology: Practical & Conceptual
4(3):214-215, 1998.
4. Ackerman AB, Nussen S. Neoplasms in all organs of Muir-Torre syndrome are carcinomas.
Méd Biol Environn
26(2):139-141, 1998.
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