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Dermatopathology: Practical & Conceptual January - March 2006
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5. New Heights: An assist to the next (10th) edition of “Lever’s”
Renata A. Joffe, M.D.
Content
Introduction
1. Small plaque parapsoriasis
2. Dysplastic nevus
3. Solar keratosis
4. Inverted follicular keratosis/trichilemmoma
5. Discoid lupus erythematosus vs. systemic lupus erythematosus
6. Lentigo maligna
7. Atopic dermatitis
8. Sebaceous adenoma
9. Muir-Torre syndrome
10. Bowen’s disease
11. Follicular mucinosis/alopecia mucinosa
12. Granuloma faciale and erythema elevatum diutinum
13. Follicular degeneration syndrome
14. Eccrine papillary adenoma
15. Degos’ disease
16. Dermatofibroma
17. Proliferating tricholemmal cyst
18. Erythema multiforme (dermal and epidermal types)
19. Lichen sclerosus et atrophicus vs. morphea
20. Malignant melanoma (classification)
21. Malignant melanoma—ABCD’s
22. Malignant melanoma—wide/deep excision
23. Sentinel node biopsy for melanoma
24. Malignant melanoma: nontumorigenic compartment of primary malignant melanoma (radial growth phase), tumorigenic compartment of primary malignant melanoma (vertical growth phase)
25. Minimal deviation melanoma
26. Nevoid melanoma
27. Malignant melanoma—in infancy and childhood
28. Malignant blue nevus
29. MELTUMP and SAMPUS
30. Bulge activation hypothesis
Conclusion
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10. Bowen's disease
Quotation from the 9th edition of Lever's:
"Bowen's disease is an interaepidermal squamous cell carcinoma referred to also as squamous cell carcinoma in situ. Thus, it represents biologically but not morphologically a precancerous dermatosis, under which designation it was described originally in 1912."
Reference in the 9th edition to concepts contrary by A. Bernard Ackerman et al. (ABA): None.
Statements contrary by ABA:
"The term "in situ" means "in place" and when applied to a malignant neoplasm refers to neoplastic cells being confined to surface epithelium and/or to adnexal epithelium continuous with it. Of all of the neoplasms designated "in situ," the commonest by far is squamous-cell in type. The diagnosis of squamous-cell carcinoma in situ is given to squamous-cell carcinoma in all organs that possess a surface epithelium, e.g., skin, cervix, oral cavity, bladder, bronchial tree, etc. The commonest expression of squamous-cell carcinoma in situ in skin is Bowen"s disease."
Ackerman AB. Squamous-cell carcinoma in situ is not analogous to apocrine carcinoma in situ and melanoma in situ.
Dermatopathology: Practical & Conceptual
5(2):143-145, 1999.
Other works of ABA in which the ideas contrary are expressed:
1. Kim SH, Ackerman AB. Precanceroses of the oral mucosa: a myth debunked.
Dermatopathology: Practical & Conceptual
9(4), 2003.
2. Kessler GM, Ackerman AB. Nomenclature for very superficial squamous-cell carcinoma of the skin and of the cervix: a critique in historical perspective.
Dermatopathology: Practical & Conceptual
9(4), 2003.
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