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Dermatopathology: Practical & Conceptual January - March 2006
>
5. New Heights: An assist to the next (10th) edition of “Lever’s”
Renata A. Joffe, M.D.
Content
Introduction
1. Small plaque parapsoriasis
2. Dysplastic nevus
3. Solar keratosis
4. Inverted follicular keratosis/trichilemmoma
5. Discoid lupus erythematosus vs. systemic lupus erythematosus
6. Lentigo maligna
7. Atopic dermatitis
8. Sebaceous adenoma
9. Muir-Torre syndrome
10. Bowen’s disease
11. Follicular mucinosis/alopecia mucinosa
12. Granuloma faciale and erythema elevatum diutinum
13. Follicular degeneration syndrome
14. Eccrine papillary adenoma
15. Degos’ disease
16. Dermatofibroma
17. Proliferating tricholemmal cyst
18. Erythema multiforme (dermal and epidermal types)
19. Lichen sclerosus et atrophicus vs. morphea
20. Malignant melanoma (classification)
21. Malignant melanoma—ABCD’s
22. Malignant melanoma—wide/deep excision
23. Sentinel node biopsy for melanoma
24. Malignant melanoma: nontumorigenic compartment of primary malignant melanoma (radial growth phase), tumorigenic compartment of primary malignant melanoma (vertical growth phase)
25. Minimal deviation melanoma
26. Nevoid melanoma
27. Malignant melanoma—in infancy and childhood
28. Malignant blue nevus
29. MELTUMP and SAMPUS
30. Bulge activation hypothesis
Conclusion
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18. Erythema multiforme (dermal and epidermal types)
Quotation from the 9th edition of Lever's:
"The predominance of epidermal and dermal changes [in erythema multiforme] reflects the site of biopsy within an individual lesion and when, in the temporal evolution of the disease, the biopsy is taken. In addition, many cases of primarily "dermal erythema multiforme" may represent hypersensitivity reactions in which interface dermatitis is not the characteristic reaction pattern."
Reference in the 9th edition to concepts contrary by A. Bernard Ackerman et al. (ABA):
Ackerman AB, Ragaz A. Erythema multiforme.
Am J Dermatopathol.
1985 Apr;7(2):133-139.
No reference to ideas of ABA published since 1985.
Statements contrary by ABA:
"There is neither a wholly epidermal nor an entirely dermal expression of erythema multiforme; erythema multiforme is an inflammatory process that involves the dermis (the upper part of it especially), the dermo-epidermal junction, and the epidermis in characteristic, repeatable fashion."
Ackerman AB, Böer A, Bennin B, Gottlieb GJ.
Histologic Diagnosis of Inflammatory Skin Diseases,
3rd Edition. New York: Ardor Scribendi, 2005. (www.derm101.com)
Other works of ABA in which the ideas contrary are expressed:
1. Ackerman AB. Chongchitnant N, Sanchez J, Guo Y.
Histologic Diagnosis of Inflammatory Skin Diseases.
2nd edition. Baltimore: Lippincott Williams & Wilkins, 1997.
2. Ackerman AB, Ragaz A.
The Lives of Lesions: Chronology in Dermatopathology.
pp 57. Masson Publishing USA, Inc., 1984. (Now on list of Lea & Febiger, Philadelphia.)
3. Ackerman AB, Niven J, Grant-Kels J.
Differential Diagnosis in Dermatopathology.
Philadelphia: Lea & Febiger, 1982.
4. Ackerman AB.
Histologic Diagnosis of Inflammatory Skin Diseases: A Method by Pattern Analysis.
Philadelphia: Lea and Febiger, 1978.
5. Ackerman AB, Penneys NS, Clark WH Jr. Erythema multiforme exudativum: distinctive pathologic process.
Br J Dermatol
84:554-566, 1971.
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