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Dermatopathology: Practical & Conceptual January - March 2006
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5. New Heights: An assist to the next (10th) edition of “Lever’s”
Renata A. Joffe, M.D.
Content
Introduction
1. Small plaque parapsoriasis
2. Dysplastic nevus
3. Solar keratosis
4. Inverted follicular keratosis/trichilemmoma
5. Discoid lupus erythematosus vs. systemic lupus erythematosus
6. Lentigo maligna
7. Atopic dermatitis
8. Sebaceous adenoma
9. Muir-Torre syndrome
10. Bowen’s disease
11. Follicular mucinosis/alopecia mucinosa
12. Granuloma faciale and erythema elevatum diutinum
13. Follicular degeneration syndrome
14. Eccrine papillary adenoma
15. Degos’ disease
16. Dermatofibroma
17. Proliferating tricholemmal cyst
18. Erythema multiforme (dermal and epidermal types)
19. Lichen sclerosus et atrophicus vs. morphea
20. Malignant melanoma (classification)
21. Malignant melanoma—ABCD’s
22. Malignant melanoma—wide/deep excision
23. Sentinel node biopsy for melanoma
24. Malignant melanoma: nontumorigenic compartment of primary malignant melanoma (radial growth phase), tumorigenic compartment of primary malignant melanoma (vertical growth phase)
25. Minimal deviation melanoma
26. Nevoid melanoma
27. Malignant melanoma—in infancy and childhood
28. Malignant blue nevus
29. MELTUMP and SAMPUS
30. Bulge activation hypothesis
Conclusion
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22. Malignant melanoma—wide/deep excision
Quotation from the 9th edition of Lever's:
"Formerly, the margin of resection of the primary tumor was regarded by most authors as optimal at about 5 cm beyond the perimeter of the lesion. However, a narrower margin is now acceptable.X A critical review of the literature revealed no evidence of an adverse effect on outcome in terms of survival from melanoma with narrowing of margins to 1cm."
Reference in the 9th edition to concepts contrary by A. Bernard Ackerman et al. (ABA): None.
Statements contrary by ABA:
" 'How wide and deep is deep enough for excision of malignant melanoma?' The answer was just enough to remove the melanoma completely, a principle that applies equally, in theory, to all malignant neoplasms in every organ and, of course, to every biopsy that seeks also to excise a neoplasm in situ.XIt makes no sense to perform a wider excision for a thicker primary melanoma; if a surgeon wants to take more tissue, he/she should go deeper, not wider!"
Cole RN, Ackerman AB. Guidelines for care of primary cutaneous melanoma: a critique of the current policy of the American Academy of Dermatology.
Dermatopathology: Practical & Conceptual
9(4), 2003.
Other works of ABA in which the ideas contrary are expressed:
1. Exploding Myths: Melanocytic Neoplasms (video). In www.derm101.com, 2005.
2. Ackerman AB. Mythology and numerology in the sphere of melanoma.
Cancer
88(3):491-96, 2000.
3. Ackerman AB. A centimeter here, a centimeter there.
J Am Acad Dermatol.
8:279, 1996.
4. Ackerman AB, Scheiner AM. How wide and deep is wide and deep enough?
Hum Pathol.
14:743-744 (September) 1983.
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