< Current issue
Dermatopathology: Practical & Conceptual July - September 2007
7. General Pathology: What is the true nature of colonic adenoma?—Part I: Confusion and controversy—a historical literature review
Masoud Asgari, M.D.
Sheng Chen, M.D., Ph.D.
Earliest descriptions of colonic polyps
Benign, premalignant, or malignant?
Unsatisfactory classification of colonic polyps
The nature of so-called adenoma of the colon is a controversial and confusing issue for all students of this subject. Understanding the exact nature of a disease, however, is requisite to initiate appropriate treatment.
To clarify the nature of adenoma of the colon.
Series of articles including (1) review of historical literature; (2) review of current literature; (3) studies of histomorphologic features in own examples of colonic aadenoma; (4) integration based on comparison with neoplasms of the skin and breast.
Part 1 - review of the historical literature: Students of the subject were confronted with conflicting findings. On one hand the cytologic features of the colonic adenoma were those seen in malignant tumors, and on the other hand it often showed a relatively benign biologic behavior with slow growth clinically. Some thought it to be a benign neoplasm, some believed it to be a carcinoma at an early stage and others considered it neither benign nor malignant. No general agreement exists regarding the nature of colonic adenoma.
The subject of colorectal adenomatous polyp is very controversial and confusing. Its true nature remains a mystery and will be addressed further in subsequent articles in this series.
This site is made possible in part by:
Copyright © Derm101.com. All Rights Reserved.