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< Current issue
Dermatopathology: Practical & Conceptual January - March 2008
>
3. New Heights: Ultraviolet radiation is not the chief cause of basal-cell carcinoma!
Roni Dodiuk-Gad, M.D.
Shadi Damanpour
A. Bernard Ackerman, M.D.
Introduction
“Evidence” on behalf of UVR being chiefly responsible for basal-cell carcinoma (A) and refutation of that “evidence” (B)
Deficiencies serious in the methodology of studies pertinent to UVR and the supposed relationship of it to basal-cell carcinoma:
Evidence on behalf of genetic factors being crucial to development of basal-cell carcinoma:
Exogenous factors capable of inducing basal-cell carcinoma:
Discussion
Conclusion
Summary
References
SEE ALSO
-
basal-cell carcinoma
-
ultraviolet radiation
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Exogenous factors capable of inducing basal-cell carcinoma:
Radiation therapy (XRT):
"These results largely agree with those of previous studies on the risk of BCC in relation to ionizing radiation exposure."
(Lichter, 2000) [
42
]
Arsenic exposure:
"The most common arsenic-induced skin cancers are Bowen's disease (carcinoma in situ), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Arsenic-induced Bowen's disease (As-BD) is able to transform into invasive BCC and SCC."
(Yu HS, 2006) [
43
]
Chemical carcinogens:
"Other exogenous factors include . . . hydrocarbons and industrial oils (e.g. petrolatum products, coal)."
(Mehrany, 2007) [
8
]
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