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Dermatopathology: Practical & Conceptual January - March 2008
3. New Heights: Ultraviolet radiation is not the chief cause of basal-cell carcinoma!
Roni Dodiuk-Gad, M.D.
A. Bernard Ackerman, M.D.
“Evidence” on behalf of UVR being chiefly responsible for basal-cell carcinoma (A) and refutation of that “evidence” (B)
Deficiencies serious in the methodology of studies pertinent to UVR and the supposed relationship of it to basal-cell carcinoma:
Evidence on behalf of genetic factors being crucial to development of basal-cell carcinoma:
Exogenous factors capable of inducing basal-cell carcinoma:
On the basis of all that is known currently, UVR has not been shown to be a major factor in the cause of BCC of any type.
Roni Dodiuk-Gad, M.D., is from the Department of Dermatology, Ha'emek Medical Center, Afula, Israel and Shadi Damanpour is at the University of Michigan at Ann Arbor, USA. A. Bernard Ackerman, M.D., is Director Emeritus of the Ackerman Academy of Dermatopathology in New York City, where Dr. Dodiuk-Gad and Ms. Damanpour did an elective. This article was reviewed by Mihaela Costache, M.D., and Riccardo Borroni, M.D. Contact corresponding author via e-mail:
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