< Current issue
Dermatopathology: Practical & Conceptual April - June 2008
4. General Pathology: What is the true nature of colonic adenoma? Part III: It is carcinoma
a histopathology reassessment
Masoud Asgari, M.D.
Sheng Chen, M.D., Ph.D.
Definition of terms
Histology of normal colonic mucosa
Histopathologic reassessment of so-called colonic adenoma
The nature of so-called adenoma of the colon is a controversial and confusing issue for all students of this subject. Understanding the exact nature of a disease, however, is a requisite to appropriate treatment.
To clarify the nature of adenoma of the colon.
Series of articles including (1) review of historical literature; (2) review of current literature; (3) studies of histopathologic features in examples of so-called colonic adenoma; (4) integration based on comparison with neoplasms of the skin and breast.
Part III. A histopathologic reassessment of 30 cases of previously diagnosed colonic adenoma was undertaken. We found that all lesions showed histopathologic features fulfilling the criteria for diagnosis of carcinoma
, namely, cytologic features of carcinoma such as crowding, stratification, and overlapping of large hyperchromatic nuclei, loss of maturation, single cell necrosis
increased number of mitotic figures, with all neoplastic cells confined in the colonic epithelium.
The so-called colonic adenoma is not adenoma, namely, a benign neoplasm of glandular epithelium, but carcinoma
obviously a well-differentiated one.
Masoud Asgari, M.D., is a research fellow at the Ackerman Academy of Dermatopathology. Sheng Chen, M.D., Ph.D., is Chief of Dermatopathology at the Department of Pathology of the Albert Einstein College of Medicine Long Island Jewish Medical Center, New York. This article was reviewed by Rajalakshmi Tirumalae, M.D., and Syed Khadri, M.D.Contact corresponding author via e-mail:
This site is made possible in part by:
Copyright © Derm101.com. All Rights Reserved.