Carcinoma in situ of the breast

 
There are two types of CIS in the breast; one is ductal CIS (DCIS) and the other lobular CIS (LCIS). For the purpose of this article, we chose DCIS for comparison. The following figures illustrate normal breast tissue (Fig. 7) and six examples of DCIS with variation in nuclear grade and growth pattern (Figs. 8 –13).

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View Figure  		Figs. 7A-C  Normal breast tissue. Breast glandular tissue consists of ducts and acini made up of a single layer of columnar epithelial cells surrounded by a flattened layer of myoepithelial cells.

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View Figure  		Figs. 8A-C  Ductal carcinoma in situ of breast, cribriform type, intermediate nuclear grade. There is proliferation of monomorphic epithelial cells with nuclear enlargement and hyperchromasia and heterochromasia. It gives a cribriform growth pattern and is confined in expanded ducts.

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View Figure  		Figs. 9A-C  Ductal carcinoma in situ of breast, cribriform type, high nuclear grade. There is proliferation of pleomorphic epithelial cells with nuclear enlargement, hyperchromasia, heterochromasia, and presence of necrosis.

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View Figure  		Figs. 10A-C  Ductal carcinoma in situ of breast, cribriform type, intermediate to high nuclear grade. There is proliferation of pleomorphic epithelial cells with nuclear enlargement, hyperchromasia, heterochromasia, presence of necrosis, and calcification.

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View Figure  		Figs. 11A-C  Ductal carcinoma in situ of breast, solid type, intermediate to high nuclear grade. Note the presence of nuclear enlargement, hyperchromasia, heterochromasia, mitotic figures, necrosis, and calcification.

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View Figure  		Figs. 12A–C  Ductal carcinoma in situ of breast, flat/micropapillary type, high nuclear grade. Note the presence of nuclear enlargement, hyperchromasia, heterochromasia, and mitotic figures.

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View Figure  		Figs. 13A–D  Ductal carcinoma in situ of breast, micropapillary type, high nuclear grade. Note the presence of nuclear enlargement, pleomorphism, hyperchromasia, heterochromasia, and necrosis. There is also pagetoid involvement of the nipple (Paget's disease; D).