Figure 14 illustrates colonic adenoma (top,) together with both DCIS of the breast (middle) and SCCIS of the skin (bottom) for comparison. Normal tissue counterparts (Figs. 14A, E, and I) are also shown. They are shown in three entirely different epithelia (columnar epithelium of the colon, stratified squamous epithelium of the skin, and ductal epithelium of the breast), and although the growth pattern of colonic adenoma, CIS of the skin, and CIS of the breast may differ, they share many, if not all, of the histopathologic attributes used by microscopists for diagnosis of them. These common histopathologic attributes are as follows: neoplastic proliferation confined in the epithelium of origin; lack or decrease of maturation; increase of nuclear size and increase of nucleus to cytoplasm ratio; hyperchromasia; heterochromasia; increase of mitotic activity; and presence of necrosis.