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Dermatopathology: Practical & Conceptual January - March 2009
4. General Pathology: What is the true nature of colonic adenoma? Part IV: It is carcinoma
—a concept further supported via comparison with carcinoma
of the skin and of the breast
Masoud Asgari, M.D.
Sheng Chen, M.D.
of the skin
of the breast
The nature of so-called adenoma of the colon is a controversial and confusing issue for all students of this subject. Understanding the exact nature of a disease, however, is a requisite to appropriate treatment.
To clarify the nature of adenoma of the colon.
Series of articles including (1) review of historical literature; (2) review of current literature; (3) studies of histopathologic features in examples of so-called colonic adenoma; (4) integration based on comparison with neoplasms of the skin and breast.
Part IV—A histopathologic comparison of squamous cell carcinoma
of the skin, ductal carcinoma
of the breast and so-called colonic adenoma was conducted. The comparison further reinforces the notion that so-called colonic adenoma is really carcinoma
and indicates that carcinoma
is a unifying concept that can be applied to every epithelium.
The so-called colonic adenoma is not adenoma, namely, a benign neoplasm of glandular epithelium, but is carcinoma
Masoud Asgari, M.D., is a research fellow at the Ackerman Academy of Dermatopathology. Sheng Chen, M.D., Ph.D. is Chief of Dermatopathology at the Department of Pathology of the Albert Einstein College of Medicine Long Island Jewish Medical Center, New York. This article was reviewed by Rajalakshmi Tirumalae, M.D., and Syed Khadri, M.D. Contact corresponding author via e-mail:
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