Proliferations with differentiation towards epithelial adnexal structures of the skin are a difficult subject, especially because a large number of entities have been described over the last decades, similar lesions have been described under different names, unrelated lesions have been grouped under the same heading, and often lesions show overlapping features, all making it difficult to properly classify each individual case.

In the area of adnexal proliferations with sebaceous differentiation, the subject is also complicated by controversies about the biological nature of some of the lesions described, e.g., so-called sebaceous adenoma, and by the fact that some lesions seem to be extraordinarily rare—or rarely diagnosed.

Here, we address the subject of superficial epithelioma with sebaceous differentiation, a lesion of the latter category. Very few publications on the subject are found in the literature of dermatopathology. [1-11]