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Dermatopathology: Practical & Conceptual October - December 2001
Hypothesis: Degos’ Disease Is a Distinctive Pattern, Chiefly of Lupus Erythematosus, And Not a Specific Disease
Elízabeth Ball, M.D.
Amy Newburger, M.D.
A. Bernard Ackerman, M.D.
The Patient Who Sparked Our Interest
Histopathologic Findings In Chronologic Sequence
Course and Prognosis
Cause and Mechanism
The Association of Degos’ Disease and “Collagen Vascular Disorders”
Our Concept of Degos’ Disease
What is called "Degos' disease," known also as "malignant atrophic papulosis," is a distinctive pattern of disease, clinically and histopathologically, it being a "final common pathway" for several pathologic processes, chief among them lupus erythematosus. In this sense, Degos' disease is analogous to many other patterns of inflammatory disease, such as erythema multiforme, erythema nodosum, leukocytoclastic vasculitis, Sweets' syndrome, Rosai-Dorfman disease, pyoderma gangrenosum, sarcoidosis, granuloma annulare, and psoriasis. Each of the aforementioned patterns of disease has characteristic attributes morphologically, and each has different causes.
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