The subject of so-called colonic adenoma or adenomatous polyp is very controversial, confusing, and its real nature remains a mystery to date, as we have discussed previously in our review of the literature both historical and contemporary. [1,2]

In the present study we approach this issue via histopathologic reassessment of tissue sections of so-called colonic adenomas obtained from colonoscopic biopsies or surgical colectomy specimens. Based on the histopathologic findings, we conclude that so-called colonic adenoma is not adenoma at all, but carcinoma in situ.